Related Experiment Video

Updated: May 20, 2026

Phosphopeptide Enrichment Coupled with Label-free Quantitative Mass Spectrometry to Investigate the Phosphoproteome in Prostate Cancer
12:23

Phosphopeptide Enrichment Coupled with Label-free Quantitative Mass Spectrometry to Investigate the Phosphoproteome in Prostate Cancer

Published on: August 2, 2018

[Phosphoproteomics-based cancer molecular-targeting therapy and diagnostics]

Yasushi Ishihama1, Masaki Wakabayashi

  • 1Dept. of Molecular & Cellular BioAnalysis, Kyoto University, Japan.

Gan to Kagaku Ryoho. Cancer & Chemotherapy
|July 14, 2012
PubMed

Insights

Protein phosphorylation, regulated by kinases and phosphatases, controls cell functions and is vital in cancer. Phosphoproteomics offers insights into these signals for targeted cancer therapies and diagnostics.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Cellular Signaling

Context:

  • Protein phosphorylation is a fundamental post-translational modification regulating diverse cellular processes.
  • Dysregulated signaling pathways, driven by aberrant phosphorylation, are implicated in cancer development and progression.
  • Understanding these complex networks is crucial for therapeutic intervention.

Purpose:

  • To review the current landscape of phosphoproteomics.
  • To highlight the applications of phosphoproteomics in cancer research.
  • To explore its role in molecularly targeted drug discovery, therapy, and diagnostics.

Summary:

  • Phosphoproteomics enables comprehensive analysis of protein phosphorylation, providing a systems-level view of cellular signal transduction.
  • This approach is instrumental in identifying key signaling nodes and pathways altered in cancer.
  • The review covers advancements in phosphoproteomics techniques and their translation into clinical applications.

Impact:

  • Facilitates the identification of novel biomarkers for cancer diagnostics and prognostics.
  • Enables the development of more precise molecularly targeted cancer therapies.
  • Advances our understanding of cancer signaling networks, paving the way for innovative treatment strategies.

More Related Videos

Quantitative Mass Spectrometric Profiling of Cancer-cell Proteomes Derived From Liquid and Solid Tumors08:08

Quantitative Mass Spectrometric Profiling of Cancer-cell Proteomes Derived From Liquid and Solid Tumors

Published on: February 27, 2015

Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts10:27

Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts

Published on: July 25, 2020

Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Pharmacogenomics: Identification of New Drug Targets01:29

Pharmacogenomics: Identification of New Drug Targets

Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...