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Related Experiment Video

Updated: May 20, 2026

Mouse Kidney Transplantation: Models of Allograft Rejection

Mouse Kidney Transplantation: Models of Allograft Rejection

Published on: October 11, 2014

Histocompatibility considerations for kidney paired donor exchange programs.

Cathi L Murphey¹, Adam W Bingaman

¹Southwest Immunodiagnostics Inc., San Antonio, Texas 78229, USA. cathi.murphey@swid-id.com

Current Opinion in Organ Transplantation

|July 14, 2012

Summary

Kidney paired donation (KPD) improves transplant access for incompatible donor-recipient pairs. Advances in human leukocyte antigen (HLA) testing, like Luminex, enhance KPD matching success.

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Published on: February 21, 2016

Area of Science:

Immunogenetics
Transplantation immunology
Nephrology

Background:

Kidney paired donation (KPD) is a vital strategy to overcome live donor kidney incompatibility.
Histocompatibility testing is crucial for successful KPD program outcomes.

Purpose of the Study:

To review the role of histocompatibility testing in KPD programs.
To discuss technological advancements impacting KPD.

Main Methods:

Review of current literature on KPD and histocompatibility testing.
Analysis of technological advances, including Luminex single-antigen bead assays.
Discussion of novel assays like C1q and Ig subclass identification.

Main Results:

Luminex technology enables virtual cross-matching for accurate donor/recipient pairing in KPD.
Understanding assay limitations is key to maximizing Luminex's utility.
C1q and Ig subclass assays may identify clinically relevant human leukocyte antigen (HLA) antibodies.

Conclusions:

KPD is an effective method for increasing kidney transplant access for patients with incompatible donors.
Histocompatibility testing advancements have significantly contributed to KPD success.