Platelet gel: applications in dental regenerative surgery
Franco Forni1, Massimo Marzagalli, Patrizia Tesei
1Hospital Dentistry Service, Foundation IRCCS, San Matteo Hospital, Pavia, Italy.
Blood Transfusion = Trasfusione Del Sangue
|July 14, 2012
Summary
Platelet-rich plasma (PRP) gel enhances bone regeneration in dentistry. This study used 3D X-ray monitoring to confirm its effectiveness in improving bone quantity and quality for dental implants.
Area of Science:
- Dental regenerative therapy
- Biomaterials science
- Oral surgery
Background:
- Platelet growth factors from platelet-rich plasma (PRP) are utilized in dental regenerative therapies.
- PRP application promotes microvascular proliferation, osteoblast activity, and new bone formation.
- This improves the quality and quantity of bone tissue for dental applications.
Purpose of the Study:
- To evaluate bone regeneration using autologous PRP-derived platelet gel.
- To quantify bone augmentation via three-dimensional X-ray monitoring.
- To assess the efficacy and safety of PRP gel in alveolar bone regeneration.
Main Methods:
- Patients with atrophic alveolar bone were selected for regenerative treatment.
- Autologous whole blood was processed to create platelet gel.
- Three-dimensional X-ray imaging (Galileos system) was used for pre- and post-treatment analysis.
Main Results:
- Over six years, 133 patients received treatment, with 304 implants placed and a low failure rate (five cases).
- Regenerated bone comprised immature osteoid tissue with vital bone trabeculae.
- Histological analysis revealed vital bone and fibro-connective tissue in the augmented area.
Conclusions:
- A collaborative approach between transfusion and dental surgery demonstrated the effectiveness and safety of PRP gel.
- Combining small amounts of PRP with autologous bone and alloplastic materials may reduce the need for extensive bone grafting.
- Further research is needed due to sample size limitations and the absence of long-term histological data.
