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Preparation and In Vitro Characterization of Dendrimer-based Contrast Agents for Magnetic Resonance Imaging
Published on: December 4, 2016
Reduction of ringing artifacts in the arterial phase of gadoxetic acid-enhanced dynamic MR imaging
Akihiro Tanimoto1, Nobuya Higuchi, Akihisa Ueno
1Department of Diagnostic Radiology, Keio University School of Medicine, Tokyo, Japan. t-mri@tt.rim.or.jp
Purpose:
We assessed what MR imaging parameters affected ringing artifacts during the arterial phase of gadoxetic acid-enhanced dynamic magnetic resonance (MR) imaging.
Materials And Methods:
We tested various parameters, including imaging matrices, choice of either sequential or elliptical centric phase-encoding scheme, scanning time, and contrast injection rate using new simulation software on a personal computer and visually evaluated clinical MR images retrospectively using a 4-point scale to assess ringing artifacts.
Results:
The simulation study revealed that square matrices, short scanning time, slow injection rate, and sequential view ordering effectively reduced ringing artifacts, findings confirmed in clinical practice using gadoxetic acid-enhanced MR imaging. Significantly fewer artifacts resulted using a slow injection rate (P<0.05) and using square matrices in the arterial (P<0.05), portal (P<0.01), and hepatocytic (P<0.05) phases.
Conclusion:
Choice of square matrix, slower injection rate, shorter scanning time, and sequential view ordering could reduce ringing artifacts.
Insights
Optimizing magnetic resonance (MR) imaging for gadoxetic acid-enhanced dynamic scans involves adjusting parameters to reduce ringing artifacts. Using square matrices, shorter scan times, and slower contrast injection rates significantly minimizes these visual disruptions.
Area of Science:
- Radiology
- Medical Imaging
- Magnetic Resonance Imaging
Background:
- Ringing artifacts can degrade image quality in dynamic contrast-enhanced MR imaging.
- Gadoxetic acid-enhanced dynamic MR imaging is crucial for liver lesion characterization.
- Minimizing artifacts is essential for accurate diagnostic interpretation.
Purpose of the Study:
- To identify key magnetic resonance (MR) imaging parameters influencing ringing artifacts.
- To evaluate the impact of different imaging parameters on artifact severity during the arterial phase of gadoxetic acid-enhanced dynamic MR imaging.
Main Methods:
- Utilized novel simulation software for parameter testing.
- Assessed imaging matrices, phase-encoding schemes (sequential vs. elliptical centric), scanning time, and contrast injection rates.
- Retrospectively evaluated clinical MR images using a 4-point scale for artifact assessment.
Main Results:
- Simulation and clinical studies confirmed that square matrices, shorter scanning times, slower contrast injection rates, and sequential view ordering reduce ringing artifacts.
- A slow injection rate significantly decreased artifacts (P<0.05).
- Square matrices demonstrated significant artifact reduction across arterial (P<0.05), portal (P<0.01), and hepatocytic (P<0.05) phases.
Conclusions:
- Square matrix selection is effective in reducing ringing artifacts.
- Slower contrast injection rates and shorter scanning times contribute to artifact mitigation.
- Sequential view ordering can also help minimize ringing artifacts in gadoxetic acid-enhanced dynamic MR imaging.
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