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Bio-switchable optofluidic lasers based on DNA Holliday junctions.

Xingwang Zhang¹, Wonsuk Lee, Xudong Fan

¹Department of Biomedical Engineering, University of Michigan, 1101 Beal Avenue, Ann Arbor, Michigan 48109, USA.

|July 14, 2012

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Researchers developed bio-switchable optofluidic lasers using DNA Holliday junctions. These lasers achieve nearly 100% wavelength switching by controlling DNA structure with magnesium ions.

Area of Science:

Optofluidics
Biophysics
DNA nanotechnology

Background:

Optofluidic lasers offer tunable wavelength emission.
DNA Holliday junctions are versatile nanostructures capable of conformational changes.

Purpose of the Study:

To demonstrate bio-switchable optofluidic lasers utilizing DNA Holliday junctions.
To investigate the control of laser wavelength through DNA conformational changes.

Main Methods:

Fabrication of optofluidic laser devices incorporating DNA Holliday junctions.
Modulation of magnesium ionic strength to induce reversible conformational changes in DNA Holliday junctions.
Optical characterization of laser emission wavelength switching.

Main Results:

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Successful demonstration of bio-switchable optofluidic lasers.
Achieved nearly 100% wavelength switching efficiency.
Confirmed the correlation between magnesium ionic strength and DNA Holliday junction conformation, leading to wavelength control.

Conclusions:

DNA Holliday junctions can serve as effective bio-switchable elements in optofluidic laser systems.
Magnesium ion concentration is a viable method for precise control of laser wavelength in these DNA-based devices.
This work opens avenues for novel tunable optical devices based on DNA nanostructures.