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[Analyses of plasma thrombopoietin levels in patients with thrombocytopenia]

Yasunobu Abe1, Ilseung Choi, Motohiko Ikeda

  • 1Division of Hematology, National Kyushu Cancer Center, National Hospital Organization, and Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University.

[Rinsho Ketsueki] the Japanese Journal of Clinical Hematology
|July 14, 2012
PubMed

We measured plasma levels of thrombopoietin (TPO) in several patients with thrombocytopenia. Similar to previous reports, TPO levels in aplastic anemia (N=9) were markedly higher than those in idiopathic thrombocytopenic purpura (N=10): 16.19+/-9.07 fmol/ml and 1.21+/-1.06 fmol/ml, respectively. In patients with secondary failure of platelet recovery (N=7) as well as primary failure after hematopoietic stem cell transplantation, TPO levels were very high, reflecting impaired platelet production due to GVHD, drug treatments, and infection. When using new drugs such as TPO-receptor agonists, measurement of TPO levels might be important to differentiate the mechanism of thrombocytopenia.

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