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Related Experiment Video

Updated: May 20, 2026

How to Measure Cortical Folding from MR Images: a Step-by-Step Tutorial to Compute Local Gyrification Index
09:57

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Published on: January 2, 2012

Superior temporal gyrus thickness correlates with cognitive performance in multiple sclerosis.

Asaf Achiron1, Joab Chapman, Sigal Tal

  • 1Department of Neurology, Multiple Sclerosis Center, Sheba Medical Center, Sackler School of Medicine, Tel-Aviv University, Tel-Hashomer, Israel. Achironasaf@gmail.com

Brain Structure & Function
|July 14, 2012
PubMed
Summary

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Relapsing-remitting multiple sclerosis (RRMS) is linked to gray matter loss, particularly in the superior temporal gyrus. This cortical thinning in RRMS patients correlates with deficits in motor skills, attention, and processing speed.

Area of Science:

  • Neuroimaging
  • Neurology
  • Cognitive Neuroscience

Background:

  • Relapsing-remitting multiple sclerosis (RRMS) involves gray matter pathology, impacting cognitive function.
  • Cortical thickness changes in RRMS require further investigation.

Purpose of the Study:

  • To investigate cortical thickness differences between RRMS patients and healthy controls.
  • To examine the relationship between cortical atrophy and cognitive performance in RRMS.

Main Methods:

  • High-field 3.0 T MRI was used to measure cortical thickness in 82 regions of the brain.
  • 20 RRMS patients and 20 age-matched healthy controls underwent MRI and cognitive testing.

Main Results:

  • Seven brain regions showed significant cortical tissue loss in RRMS patients, primarily in frontal and temporal lobes.

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Last Updated: May 20, 2026

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Published on: January 2, 2012

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Published on: July 19, 2019

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  • Increased cortical thickness was observed in visual sensory areas, suggesting adaptive plasticity.
  • Left hemisphere superior temporal gyrus thinning correlated with reduced motor skills, attention, and information processing speed.

    • Conclusions:

    • Mild RRMS is associated with localized cortical thinning.
    • Atrophy in the left superior temporal gyrus is linked to cognitive impairment in RRMS patients.