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Updated: May 20, 2026

Discovery and Synthesis Optimization of Isoreticular Al(III) Phosphonate-Based Metal-Organic Framework Compounds Using High-Throughput Methods
Published on: October 6, 2023
Green synthesis and bioactivity of 2-amino-4H-chromen-4-yl-phosphonates
Mekala Rajasekhar1, Kunda Uma Maheswara Rao, Chereddy Syama Sundar
1Department of Chemistry, Sri Venkateswara University, Tirupati, India.
Abstract:
A simple and efficient one pot synthesis of 2-amino-4H-chromen-4-yl phosphonate derivatives has been accomplished by the condensation of salicylaldehyde, malononitrile/ethylcyanoacetate and triethyl phosphite/trimethyl phosphite in the presence of molecular iodine as catalyst in water at room temperature. All the reactions were very clean and the products were obtained in very good to excellent yields. The title compounds are characterized by IR, 1H-, 13C-, 31P-NMR and mass spectra, also studied their antimicrobial and antioxidant activity.
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