Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

IP3/DAG Signaling Pathway01:11

IP3/DAG Signaling Pathway

Membrane lipids such as phosphatidylinositol (PI) are precursors for several membrane-bound and soluble second messengers. Specific kinases phosphorylate PI and produce phosphorylated inositol phospholipids. One such inositol phospholipids are the  phosphatidylinositol-4,5 bisphosphate [PI(4,5)P2], present in the inner half of the lipid bilayer. Upon ligand binding, GPCR stimulates Gq proteins to turn on phospholipase Cꞵ. Activated phospholipase Cꞵ cleaves PI(4,5)P2 and produces two-second...
Physical Properties of Amines01:26

Physical Properties of Amines

Amines with low molecular weight are usually gaseous at room temperature, while those with high molecular weight are liquid or solids in nature. Usually, low molecular weight amines have a rotten fish-like smell. Diamines typically have a pungent smell. For instance, cadaverine and putrescine, depicted in Figure 1, are two molecules responsible for decaying tissue.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Differentiating Main-Duct IPMN from Chronic Pancreatitis Using Next-Generation Sequencing of Main Pancreatic Duct Fluid: A Pilot Study.

Diagnostics (Basel, Switzerland)·2025
Same author

From FAIR to CURE: Guidelines for Computational Models of Biological Systems.

ArXiv·2025
Same author

A decision point between transdifferentiation and programmed cell death priming controls KRAS-dependent pancreatic cancer development.

Nature communications·2025
Same author

Metavert synergises with standard cytotoxics in human PDAC organoids and is associated with transcriptomic signatures of therapeutic response.

Translational oncology·2024
Same author

The radiomorphological appearance of the invasive margin in pancreatic cancer is associated with tumor budding.

Langenbeck's archives of surgery·2024
Same author

N-cadherin: A diagnostic marker to help discriminate primary liver carcinomas from extrahepatic carcinomas.

International journal of cancer·2024
Same journal

Real-world Safety and Performance of the Symani Surgical System® in Microsurgical Reconstructive Procedures: Primary Results from the PRIMO Study.

Annals of surgery·2026
Same journal

Revisiting Simultaneous Liver and Kidney Transplantation from Donors After Circulatory Death in the Era of Machine Perfusion Technologies: A US Nationwide Analysis of 10,687 Cases.

Annals of surgery·2026
Same journal

The International Medical Graduate Paradox.

Annals of surgery·2026
Same journal

Defining the Incremental Value of Endoscopic Ultrasound in Assessing Pancreatic Cystic Neoplasms.

Annals of surgery·2026
Same journal

Trends in Metabolic and Bariatric Surgery and GLP-1 Receptor Agonist Use Among Adolescents with Severe Obesity.

Annals of surgery·2026
Same journal

The Ambulatory Surgery Center Paradox: Why 60% of Surgeries Occur Where 2% of AI Research Happens.

Annals of surgery·2026
See all related articles

Related Experiment Video

Updated: May 20, 2026

Double-stranded RNA Oral Delivery Methods to Induce RNA Interference in Phloem and Plant-sap-feeding Hemipteran Insects
10:14

Double-stranded RNA Oral Delivery Methods to Induce RNA Interference in Phloem and Plant-sap-feeding Hemipteran Insects

Published on: May 4, 2018

Small (Sendai negative) branch-duct IPMNs: not harmless.

Stefan Fritz1, Miriam Klauss, Frank Bergmann

  • 1Department of General and Visceral Surgery, University of Heidelberg, Heidelberg, Germany.

Annals of Surgery
|July 14, 2012
PubMed
Summary
This summary is machine-generated.

Current guidelines for branch-duct intraductal papillary mucinous neoplasms (IPMNs) may underestimate malignancy risk. Many "Sendai negative" IPMNs show cancerous changes, necessitating guideline adjustments for better patient management.

More Related Videos

Evaluating Dryocosmus Kuriphilus-induced Damage on Castanea Sativa
07:14

Evaluating Dryocosmus Kuriphilus-induced Damage on Castanea Sativa

Published on: August 30, 2018

Robotic Duodenum-preserving Total Pancreatic Head Resection for Intraductal Papillary Mucinous Neoplasms
10:10

Robotic Duodenum-preserving Total Pancreatic Head Resection for Intraductal Papillary Mucinous Neoplasms

Published on: April 17, 2026

Related Experiment Videos

Last Updated: May 20, 2026

Double-stranded RNA Oral Delivery Methods to Induce RNA Interference in Phloem and Plant-sap-feeding Hemipteran Insects
10:14

Double-stranded RNA Oral Delivery Methods to Induce RNA Interference in Phloem and Plant-sap-feeding Hemipteran Insects

Published on: May 4, 2018

Evaluating Dryocosmus Kuriphilus-induced Damage on Castanea Sativa
07:14

Evaluating Dryocosmus Kuriphilus-induced Damage on Castanea Sativa

Published on: August 30, 2018

Robotic Duodenum-preserving Total Pancreatic Head Resection for Intraductal Papillary Mucinous Neoplasms
10:10

Robotic Duodenum-preserving Total Pancreatic Head Resection for Intraductal Papillary Mucinous Neoplasms

Published on: April 17, 2026

Area of Science:

  • Gastroenterology
  • Surgical Oncology
  • Pancreatic Pathology

Background:

  • Current Sendai criteria recommend conservative management for asymptomatic, small (<3 cm) branch-duct IPMNs without suspicious imaging features.
  • A significant risk of malignancy persists even in IPMNs that appear benign on preoperative imaging.

Purpose of the Study:

  • To evaluate the effectiveness of current management guidelines for branch-duct IPMNs.
  • To assess the actual risk of malignancy in IPMNs classified as "Sendai negative".

Main Methods:

  • Retrospective analysis of 287 surgically resected IPMNs (January 2004 - July 2010).
  • Detailed examination of clinical characteristics and preoperative imaging for 123 branch-duct IPMNs.
  • Correlation of imaging findings with histopathological results.

Main Results:

  • Of 69 "Sendai negative" branch-duct IPMNs (<3 cm, no suspicious features), 24.6% harbored malignancy (invasive carcinoma or carcinoma in situ).
  • Histopathological analysis revealed malignant features in a substantial proportion of IPMNs initially deemed low-risk.

Conclusions:

  • Branch-duct IPMNs, even small and asymptomatic ones, present a significant risk of malignancy.
  • Both main-duct and branch-duct IPMNs should be considered premalignant lesions requiring careful therapeutic consideration.
  • The current Sendai criteria require revision to better identify and manage malignant potential in branch-duct IPMNs.