Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Acute Respiratory Failure-III01:30

Acute Respiratory Failure-III

Hypercapnic respiratory failure, also known as Type 2 or ventilatory respiratory failure, is a severe condition characterized by the body's inability to effectively remove carbon dioxide (CO2) from the bloodstream. It leads to an arterial CO2 pressure (PaCO2) exceeding 45 mmHg and a blood pH above 7.35. This situation indicates that the body's ventilatory demand, or the ventilation needed to maintain normal PaCO2 levels, surpasses its supply or the maximum gas flow achievable without causing...
Acute Respiratory Failure-IV01:23

Acute Respiratory Failure-IV

Respiratory failure can manifest suddenly or gradually, characterized by a rapid decline in PaO2 and a rapid rise in PaCO2. This situation indicates a severe respiratory problem that may quickly become a life-threatening emergency. One of the early signs of hypoxemic Acute Respiratory Failure (ARF) is a change in mental status due to the brain's sensitivity to oxygen levels and changes in acid-base balance. Symptoms such as restlessness, confusion, and agitation suggest inadequate oxygen...
Acute Respiratory Failure-II01:21

Acute Respiratory Failure-II

Type I Respiratory Failure, or hypoxemic respiratory failure, occurs when the partial pressure of oxygen (PaO2) in arterial blood falls below 60 mmHg while breathing room air without a corresponding increase in arterial carbon dioxide levels (PaCO2). This condition highlights a significant impairment in the lungs' capacity to oxygenate the blood.
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
Diabetes Insipidus II: Pathophysiology01:22

Diabetes Insipidus II: Pathophysiology

Normally, water balance is maintained through three interconnected mechanisms: the hypothalamic thirst center, the synthesis and release of antidiuretic hormone (ADH, or vasopressin), and the kidneys' responsiveness to this hormone. ADH is synthesized in the hypothalamus, released from the posterior pituitary, and acts on the distal nephron, allowing water reabsorption and concentrated urine production.Diabetes Insipidus and Its TypesIn diabetes insipidus (DI), this regulatory system is...
Acute Respiratory Failure-V01:29

Acute Respiratory Failure-V

The treatment for acute respiratory failure varies based on factors like the underlying cause, overall health, and severity. A collaborative healthcare team is essential for early detection, often through arterial blood gas analysis. Identifying the cause is the primary goal, with treatment strategies adjusted for ventilation/perfusion (V/Q) mismatch, shunting, or diffusion impairment.
Ensure that patients are monitored continuously for their response to therapy, including changes in...
Diabetes Insipidus I: Introduction01:29

Diabetes Insipidus I: Introduction

Definition Diabetes insipidus is a disorder marked by the production of large amounts of dilute urine because of impaired vasopressin production, release, or kidney response. The lack of effective vasopressin action limits water reabsorption in the renal collecting ducts, which leads to excessive urinary water loss and intense thirst.Clinical PresentationIndividuals with diabetes insipidus report persistent thirst and very high urine output. In severe cases, fluid intake can reach up to 20...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Treatment of Leukemic Blood Samples with Granulocyte-Macrophage-Colony-Stimulating-Factor Combined with Prostaglandin E1 Is Associated with Reduced Frequencies of Tolerogenic Dendritic Cells and Increased Cytotoxicity Against Autologous Blasts.

Biomedicines·2026
Same author

The Role of Chirality-Induced Spin Selectivity in Helicene-Based Photogenerated Radical Pairs.

Journal of the American Chemical Society·2026
Same author

Oral Microbiota Characteristics in Relation to Different Dietary Patterns: A Systematic Review.

Nutrients·2026
Same author

Modulation of Leukemic Blasts into Dendritic Cells (DC<sub>leu</sub>) and Their Role in Predicting Survival in Patients with AML and MDS.

Cancers·2026
Same author

Light-Activated Qubit Coupling in a Vanadyl Porphyrin Trimer.

Journal of the American Chemical Society·2026
Same author

Impact of FMS-like tyrosine kinase 3 inhibitor maintenance on post-transplant outcomes in acute myeloid leukemia with FMS-like tyrosine kinase 3 mutations: a real-world German registry analysis highlighting sorafenib.

Haematologica·2026
Same journal

Central serous chorioretinopathy associated with topical prostaglandin analogues.

BMJ case reports·2026
Same journal

Aberrant macular artery with absent foveal pit and retained inner retinal layers.

BMJ case reports·2026
Same journal

Post-traumatic cervical dystonia treated with botulinum toxin type A injections to the cranial and cervical muscles.

BMJ case reports·2026
Same journal

Light chain-mediated acute tubulointerstitial nephritis as the sole manifestation of monoclonal gammopathy of renal significance in a young adult.

BMJ case reports·2026
Same journal

Late diagnosis of late onset Fabry disease.

BMJ case reports·2026
Same journal

Pelvic desmoid fibromatosis: a diagnostic and therapeutic challenge.

BMJ case reports·2026
See all related articles

Related Experiment Video

Updated: May 20, 2026

Surfactant Depletion Combined with Injurious Ventilation Results in a Reproducible Model of the Acute Respiratory Distress Syndrome (ARDS)
06:22

Surfactant Depletion Combined with Injurious Ventilation Results in a Reproducible Model of the Acute Respiratory Distress Syndrome (ARDS)

Published on: April 7, 2021

Vanishing polyuria and respiratory failure.

Fabio Ruggieri1, Alessandro Chiesa, Kathleen Schorn

  • 1Department of Internal Medicine, Division of General Internal Medicine, University of Zurich, Zurich, Switzerland. statale113@hotmail.com

BMJ Case Reports
|July 14, 2012
PubMed
Summary
This summary is machine-generated.

A parathyroid adenoma caused a severe hypercalcaemic crisis leading to multi-organ failure. Surgical removal of the adenoma resolved the condition, restoring normal lung function.

More Related Videos

Simplified Whole Body Plethysmography to Characterize Lung Function During Respiratory Melioidosis
07:27

Simplified Whole Body Plethysmography to Characterize Lung Function During Respiratory Melioidosis

Published on: February 24, 2023

A Porcine Model of Acute Respiratory Failure with a Continuous Infusion of Oleic Acid
04:10

A Porcine Model of Acute Respiratory Failure with a Continuous Infusion of Oleic Acid

Published on: March 8, 2024

Related Experiment Videos

Last Updated: May 20, 2026

Surfactant Depletion Combined with Injurious Ventilation Results in a Reproducible Model of the Acute Respiratory Distress Syndrome (ARDS)
06:22

Surfactant Depletion Combined with Injurious Ventilation Results in a Reproducible Model of the Acute Respiratory Distress Syndrome (ARDS)

Published on: April 7, 2021

Simplified Whole Body Plethysmography to Characterize Lung Function During Respiratory Melioidosis
07:27

Simplified Whole Body Plethysmography to Characterize Lung Function During Respiratory Melioidosis

Published on: February 24, 2023

A Porcine Model of Acute Respiratory Failure with a Continuous Infusion of Oleic Acid
04:10

A Porcine Model of Acute Respiratory Failure with a Continuous Infusion of Oleic Acid

Published on: March 8, 2024

Area of Science:

  • Endocrinology
  • Nephrology
  • Critical Care Medicine

Background:

  • Hypercalcaemic crisis can lead to severe complications, including renal failure and multi-organ dysfunction.
  • Parathyroid adenomas are a common cause of hypercalcemia, but can present with severe, life-threatening symptoms.

Observation:

  • A 44-year-old male presented with symptoms of hypercalcaemic crisis, including headache, sweating, fever, and fatigue, complicated by acute renal failure.
  • Despite initial treatment, the patient's condition deteriorated, leading to anuria, multi-organ failure, and acute respiratory distress syndrome requiring intensive support.
  • Widespread ectopic calcification was noted in multiple organs, including the lungs, thyroid, kidneys, heart, and stomach.

Findings:

  • Surgical excision of a large parathyroid adenoma was performed.
  • Post-operatively, the patient's calcium levels normalized, and his organ function improved.
  • Eleven months after surgery, the patient had recovered significantly, with normal oxygen requirements and restored total lung capacity.

Implications:

  • Surgical intervention for parathyroid adenomas causing hypercalcaemic crisis is crucial for patient survival and recovery.
  • Early diagnosis and management of hypercalcemia can prevent severe complications like ectopic calcification and multi-organ failure.
  • This case highlights the potential for significant recovery following timely treatment of severe endocrine emergencies.