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Related Experiment Video

Updated: May 20, 2026

Implementation of Non-invasive Point of Care Transient Elastography for Evaluation of Liver Disease in Pediatric Populations with Cystic Fibrosis

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Recurrent vasculitis in cystic fibrosis.

Lareina Wujanto¹, Clare Ross

¹Dermatology Department, Ealing Hospital, Southall, Middlesex, UK. reinawujanto@gmail.com

BMJ Case Reports

|July 14, 2012

Summary

Cystic fibrosis (CF) can cause rare skin issues like CF-related vasculitis, appearing as a purpuric rash. This vasculitis, an extrapulmonary manifestation, can occur during infective exacerbations of CF.

Area of Science:

Medicine
Dermatology
Pulmonology

Background:

Cystic Fibrosis (CF) is a genetic disorder affecting multiple organs.
Extrapulmonary manifestations of CF are less common but significant.
Vasculitis is an inflammation of blood vessels.

Observation:

A 22-year-old male with known Cystic Fibrosis (CF) presented with a recurrent palpable purpuric rash.
The rash, identified as CF-related vasculitis, predominantly affected the lower limbs.
The onset coincided with an infective exacerbation of CF (IECF), but also occurred independently.

Findings:

CF-related vasculitis is a rare, extrapulmonary manifestation of Cystic Fibrosis.
The condition presents as a purpuric rash, typically on the lower extremities.

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The rash showed spontaneous remission in some instances but required immunosuppression in others.

Implications:

Highlights the diverse clinical spectrum of Cystic Fibrosis.
Suggests a need for heightened awareness of vasculitis in CF patients.
Underscores the importance of managing both pulmonary and extrapulmonary complications in CF.