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Disease course in steroid sensitive nephrotic syndrome
Aditi Sinha1, Pankaj Hari, Piyush Kumar Sharma
1Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India.
Indian Pediatrics
|July 14, 2012
Summary
Steroid sensitive nephrotic syndrome (SSNS) frequently leads to relapses, particularly in younger children. Early onset, insufficient initial treatment, and early relapse are key risk factors for frequent relapses in SSNS patients.
Area of Science:
- Pediatric Nephrology
- Clinical Research
- Immunology
Background:
- Steroid sensitive nephrotic syndrome (SSNS) is a common kidney disorder in children.
- Understanding the long-term disease course and predictors of outcome is crucial for effective management.
Purpose of the Study:
- To review the disease course in patients with SSNS.
- To identify factors influencing the outcome of SSNS.
Main Methods:
- Retrospective analytical study of 2603 patients with SSNS evaluated between 1990 and 2005.
- Disease course categorized into infrequent relapses (IFR) and frequent relapses/steroid dependence (FR) based on at least one year of follow-up.
- Analysis of complications, alternative therapies, and risk factors for disease course.
Main Results:
- Over 56% of patients experienced frequent relapses (FR) within the first year.
- Patients with FR were younger, received less adequate initial treatment, and had shorter initial remission periods compared to those with IFR.
- Serious infections occurred in 224 patients during follow-up.
Conclusions:
- A significant proportion of children with SSNS exhibit frequent relapses.
- Early age at onset, inadequate initial therapy, and early relapse are significant risk factors for frequent relapses in SSNS.
- Long-term remission or infrequent relapses were observed in 77.3% of patients.
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