Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Staphylococcal Skin Infections01:29

Staphylococcal Skin Infections

Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Burn Injuries01:22

Burn Injuries

Burn injuries occur when the skin and underlying tissues are damaged due to exposure to heat, electricity, chemicals, radiation, or friction. They can vary in severity, from minor superficial burns to severe deep burns that can be life-threatening.
The damage results in the death of skin cells, which can lead to a massive loss of fluid. Dehydration, electrolyte imbalance, and renal and circulatory failure follow, which can be fatal. Burn patients are treated with intravenous fluids to offset...
Gastritis III: Clinical Manifestations and Management01:23

Gastritis III: Clinical Manifestations and Management

The clinical manifestations of gastritis can vary depending on the cause and type of gastritis, but some common symptoms may include the following.
Clinical manifestations of acute gastritis
The patient with acute gastritis may have a rapid onset of symptoms, such as epigastric pain or discomfort, dyspepsia, anorexia, hiccups, or nausea and vomiting, which can last from a few hours to a few days. Erosive or hemorrhagic gastritis may cause bleeding, which may manifest as blood in vomit or as...
Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Indian Academy of Pediatrics Guidelines on Screen Time and Digital Wellness in Infants, Children and Adolescents.

Indian pediatrics·2021
Same author

Dermatofibrosarcoma protuberans: Two rare variants.

Indian journal of dermatology, venereology and leprology·2019
Same author

Genetic Diagnosis in an Indian Child with Alagille Syndrome.

Indian journal of pediatrics·2015
Same author

Kocher-Debre-Semelaigne syndrome.

BMJ case reports·2012
Same author

A child with delayed milestones and interesting findings on MR.

BMJ case reports·2012
Same author

Patent vitellointestinal duct.

BMJ case reports·2012
Same journal

Early onset cerebral oedema in adult diabetic ketoacidosis with complete resolution.

BMJ case reports·2026
Same journal

Third salvage haematopoietic stem cell transplantation in a child with very early-onset IBD due to interleukin-10 receptor deficiency.

BMJ case reports·2026
Same journal

Fungal keratitis caused by <i>Trichomonascus ciferrii</i> in an immunocompetent adult.

BMJ case reports·2026
Same journal

An unusual cause of acute small bowel obstruction in a child: multiple trichobezoars diagnosed on CT.

BMJ case reports·2026
Same journal

Massive haemoptysis secondary to pulmonary artery aneurysms in Hughes-Stovin syndrome: a variant of Behçet's disease managed with immunosuppression and endovascular embolisation.

BMJ case reports·2026
Same journal

The blue dilemma: a rare presentation of dual hemoglobinopathy in a pregnant patient.

BMJ case reports·2026
See all related articles

Related Experiment Videos

Pyoderma gangrenosum.

Sanwar Agrawal1, Bharat Singhania

  • 1Department of Pediatrics, Ekta Institute of Child Health, Raipur, India. drsanwar50@gmail.com

BMJ Case Reports
|July 14, 2012
PubMed
Summary
This summary is machine-generated.

Pyoderma gangrenosum is a rare skin condition causing painful ulcers. This case highlights its presentation in a young child, emphasizing the importance of histopathology for diagnosis.

Related Experiment Videos

Area of Science:

  • Dermatology
  • Pediatric Dermatology
  • Pathology

Background:

  • Pyoderma gangrenosum (PG) is a neutrophilic dermatosis characterized by ulcerative skin lesions.
  • Diagnosis can be challenging due to its varied presentation and exclusion of other conditions.
  • Early recognition and accurate diagnosis are crucial for effective management.

Observation:

  • A 3.5-year-old girl presented with a history of skin lesions evolving from pustules to painful ulcers with raised, irregular borders.
  • Active ulcers were noted on the left elbow, with evidence of healed, scarred lesions on the trunk and thighs.
  • The child had no relevant autoimmune markers, viral hepatitis, or gastrointestinal symptoms, and a normal colonoscopy.

Findings:

  • Histopathological examination of the skin lesions was diagnostic for pyoderma gangrenosum.
  • The clinical presentation and negative workup for other conditions supported the diagnosis of PG in this pediatric patient.

Implications:

  • This case underscores the importance of considering pyoderma gangrenosum in pediatric patients with unexplained ulcerative skin lesions.
  • Accurate histopathological diagnosis is essential for differentiating PG from other ulcerative dermatoses.
  • Timely diagnosis and appropriate treatment can prevent further disease progression and minimize scarring.