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Secondary Lymphoid Organs

Secondary Lymphoid Organs

Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...

Hepatic Portal System

Hepatic Portal System

The hepatic portal system, a critical part of our circulatory framework, transports nutrient-laden, deoxygenated blood from the gastrointestinal tract and spleen to the liver. This ingenious system plays an indispensable role in maintaining our body's metabolic equilibrium.
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Lifecycle of Erythrocytes

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Erythrocytes, also known as red blood cells, constantly move through blood capillaries. As a result, they damage their plasma membrane due to the continuous friction. Typically, after 100 to 120 days, erythrocytes become rigid and fragile as they wear out. As they pass through small vessels in the spleen and liver, they can get trapped and break apart into fragments.
The resident phagocytic macrophages deal with these damaged cells by engulfing them and separating their globin and heme groups.

Capillaries and Their Types

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Blood Supply to the Digestive System

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Related Experiment Video

Updated: May 20, 2026

A Mouse Model of Vascularized Heterotopic Spleen Transplantation for Studying Spleen Cell Biology and Transplant Immunity

A Mouse Model of Vascularized Heterotopic Spleen Transplantation for Studying Spleen Cell Biology and Transplant Immunity

Published on: June 11, 2019

What does the spleen see?

Stanley L Schrier¹

¹Stanford University School of Medicine.

|July 14, 2012

Summary

This summary is machine-generated.

This study investigates how red blood cells (RBCs) are removed in diseases like hereditary spherocytosis and autoimmune hemolytic anemia, shedding light on RBC senescence.

More Related Videos

Intravital Microscopy of the Spleen: Quantitative Analysis of Parasite Mobility and Blood Flow

Intravital Microscopy of the Spleen: Quantitative Analysis of Parasite Mobility and Blood Flow

Published on: January 14, 2012

Related Experiment Videos

Last Updated: May 20, 2026

A Mouse Model of Vascularized Heterotopic Spleen Transplantation for Studying Spleen Cell Biology and Transplant Immunity

A Mouse Model of Vascularized Heterotopic Spleen Transplantation for Studying Spleen Cell Biology and Transplant Immunity

Published on: June 11, 2019

Intravital Microscopy of the Spleen: Quantitative Analysis of Parasite Mobility and Blood Flow

Intravital Microscopy of the Spleen: Quantitative Analysis of Parasite Mobility and Blood Flow

Published on: January 14, 2012

Area of Science:

Red blood cell (RBC) biology and pathophysiology.

Background:

Investigates the mechanisms of RBC removal in specific hemolytic anemias.
Addresses the complex process of RBC senescence.

Discussion:

Explores the link between RBC removal mechanisms and RBC aging.
Provides insights into conditions such as hereditary spherocytosis and autoimmune hemolytic anemia.

Key Insights:

Elucidates critical pathways involved in the clearance of aged and damaged RBCs.
Highlights the role of senescence in RBC removal during hemolytic disorders.

Outlook:

Suggests potential therapeutic targets for managing RBC disorders.
Opens avenues for further research into RBC homeostasis and disease.