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A neuroendocrine view of ECT
S J Cooper1, A I Scott, L J Whalley
1Department of Mental Health, Queen's University of Belfast.
The British Journal of Psychiatry : the Journal of Mental Science
|November 1, 1990
Abstract:
"A neuroendocrine hypothesis to explain the clinical activity of convulsive therapy is described. The hypothesis is based on the diabetes/insulin model and suggests that hypothalamic dysfunction with an insufficiency of a mood-maintaining peptide is the basis for affective disorders. Repeated seizures enhance the production and release of the hypothalamic peptide antidepressin - the active principle that relieves both neuroendocrine and behavioral abnormalities.