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Updated: May 20, 2026

Preparation and Characterization of Nanoliposomes for the Entrapment of Bioactive Hydrophilic Globular Proteins
Published on: August 31, 2019
Encapsulation of Liposomes within pH Responsive Microspheres for Oral Colonic Drug Delivery
M J Barea1, M J Jenkins, Y S Lee
1Centre for Formulation Engineering, School of Chemical Engineering, University of Birmingham, Edgbaston B15 2TT, UK.
Abstract:
A novel liposome-in-microsphere (LIM) formulation has been created comprising drug-loaded liposomes within pH responsive Eudragit S100 microspheres. The liposomes contained the model drug 5-ASA and were coated with chitosan in order to protect them during encapsulation within the microspheres and to improve site-specific release characteristics. In vitro drug release studies showed that LIMs prevented drug release within simulated stomach and small intestine conditions with subsequent drug release occurring in large intestine conditions. The formulation therefore has potential for oral colonic drug delivery.
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