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MALDI-TOF Mass Spectrometry01:19

MALDI-TOF Mass Spectrometry

Mass spectrometry is a powerful characterization technique that can identify and separate a wide variety of compounds ranging from chemical to biological entities, based on their mass-to-charge ratio (m/z). The instruments that allow this detection, known as mass spectrometers, have three components: an ion source, a mass analyzer, and a detector. These spectrometers differ based on the nature of their ion source and analyzers.Matrix-assisted laser desorption ionization (MALDI) is a commonly...
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Tandem mass spectrometry is a technique that uses multiple mass analyzers in series to obtain a higher selectivity and reduce chemical noise during analyte detection. Instruments with multiple analyzers separated by an interaction cell enable secondary fragmentation and selected study of the fragment ions.Secondary fragmentations occur in the interaction cell and can be induced by various factors. Fragmentation induced by collision with inert gases, such as N2, Ar, He, etc., is called...
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Mass spectrometry is an important technique for the identification of pure compounds. However, it has some limitations for the analysis of complex mixtures, often due to excessive fragmentation making the spectrum too complicated to decipher. Mass spectrometry can be combined with suitable separation methods in sequence, forming hyphenated methods, which are useful in the analysis of complex mixtures.
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Mass spectrometry is an analytical technique used to determine the molecular mass and molecular formula of a compound. The basic principle of mass spectrometry is to generate ions from the analyte molecule and measure these ion abundances against their molecular mass. One common type of ionization, known as electron ionization or EI, bombards the analyte molecules in the gas phase with high-energy electron beams. The electron beams displace an electron from the molecule and leave behind a...

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Mass spectrometry in India.

M Vairamani1, S Prabhakar

  • 1National Centre for Mass Spectrometry, Indian Institute of Chemical Technology, Hyderabad-500 007, Andhra Pradesh, India. vairamani@hotmail.com

European Journal of Mass Spectrometry (Chichester, England)
|July 17, 2012
PubMed
Summary

Mass spectrometry research in India spans organic, atomic, and biological fields, evolving from early chemistry applications to modern proteomics and metabolomics. Advanced facilities now attract numerous doctoral students for cutting-edge research.

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Area of Science:

  • Analytical Chemistry
  • Physical Chemistry
  • Biochemistry

Background:

  • Mass spectrometry (MS) research in India began mid-20th century, initially applied to organic, nuclear, geographical, and atomic chemistry.
  • Advancements in soft and atmospheric ionization techniques expanded MS applications to pharmaceutical and biological research.
  • Numerous specialized research centers with advanced MS facilities have been established across India.

Purpose of the Study:

  • To review the landscape of mass spectrometry research in academic and research institutions in India.
  • To highlight the historical development and current scope of MS applications in the country.
  • To showcase the diverse research areas benefiting from MS technology in India.

Main Methods:

  • Literature review of mass spectrometry research conducted in India.
  • Categorization of research into organic, atomic, and biological mass spectrometry.
  • Identification of key research institutions and their specialized MS facilities.

Main Results:

  • Mass spectrometry research in India has evolved significantly since the mid-20th century.
  • Current research encompasses a wide array of fields including proteomics, lipidomics, metabolomics, and environmental analysis.
  • India possesses advanced mass spectrometry facilities supporting diverse research endeavors.

Conclusions:

  • Mass spectrometry is a vital and growing research area in India.
  • The establishment of specialized centers has fostered advanced research and attracted young scientists.
  • Continued development in MS technology promises further innovation across scientific disciplines in India.