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A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
06:01

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia

Published on: August 18, 2015

[Gene-determined hemocoagulation disease as a cause of ischemic stroke in children]

O A L'vova, O P Kovtun, D A Chegodaev

    Zhurnal Nevrologii I Psikhiatrii Imeni S.S. Korsakova
    |July 17, 2012
    PubMed

    History of thrombosis and polymorphisms of genes of hemocoagulation system were studied in 27 children with ischemic stroke. The distribution of allelic variants in the Russian population was compared to that in other world populations. Each patient had 4 and more allelic variants of hemocoagulation's genes. The most frequent were polymorphisms G-455A FGB, C807T ITGA2 and 675 4G4G PAI-1. Thrombotic episodes and vascular events under the age of 50 were noted in the family history of 81.5% patients. The modern data on frequencies of hemocoagulation gene polymorphisms in clinical and non-clinical populations of children and their phenotypic features are analyzed.

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