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Updated: May 20, 2026
06:35
Ultrasound Assessment of Endothelial Function: A Technical Guideline of the Flow-mediated Dilation Test
Published on: April 27, 2016
[Endothelial dysfunction in ischemic strokes in diabetes mellitus]
Zhurnal Nevrologii I Psikhiatrii Imeni S.S. Korsakova
|July 17, 2012
Summary
Patients with type 2 diabetes experiencing ischemic stroke show elevated endothelial cell activation markers. This endothelial dysfunction correlates with stroke severity, highlighting a key factor in disease progression for this patient group.
Area of Science:
- Neurology
- Endocrinology
- Vascular Biology
Context:
- Ischemic stroke progression involves endothelial cell activation, particularly in individuals with type 2 diabetes mellitus.
- Understanding endothelial dysfunction is crucial for managing stroke in diabetic patients.
Purpose:
- To evaluate endothelial dysfunction in patients diagnosed with acute ischemic stroke and type 2 diabetes mellitus.
- To assess plasma von Willebrand factor (vWf) activities as a marker of endothelial cell activation in this cohort.
Summary:
- Plasma vWf activities were significantly higher in patients with ischemic stroke and type 2 diabetes compared to those with ischemic stroke and arterial hypertension, and healthy controls.
- A correlation was identified between the severity of neurological deficit at day 21 and the measured activity of endothelial dysfunction.
Impact:
- This study identifies elevated endothelial dysfunction as a significant factor in acute ischemic stroke among patients with type 2 diabetes.
- Findings suggest that vWf activity could serve as a biomarker for stroke severity and progression in diabetic patients.
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