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Updated: May 20, 2026
09:36
Applications of Liquid-Chromatography Tandem Mass Spectrometry in Natural Products Research: Tropane Alkaloids as a Case Study
Published on: March 8, 2024
[Sesquiterpenoids of Coniogramme maxima]
Yunfei Chen1, Shoujin Liu, Fei Wang
1Anhui Key Laboratory of Modernized Chinese Materia Medica, Anhui College of Traditional Chinese Medicine, Hefei 230031, China.
Summary
This study isolated fifteen compounds from Coniogramme maxima, including ten novel sesquiterpenoids. Nine of these sesquiterpenoids are reported from the Coniogramme genus for the first time.
Area of Science:
- Phytochemistry
- Natural Product Chemistry
- Organic Chemistry
Context:
- Coniogramme maxima, a plant species, is a potential source of bioactive natural products.
- Sesquiterpenoids are a diverse class of terpenes with significant pharmacological potential.
- Understanding the chemical constituents of medicinal plants is crucial for drug discovery.
Purpose:
- To isolate and characterize the sesquiterpenoids from Coniogramme maxima.
- To identify novel compounds from the Coniogramme genus.
- To contribute to the phytochemical knowledge of Coniogramme species.
Summary:
- Fifteen compounds were isolated from Coniogramme maxima using chromatographic techniques.
- Ten sesquiterpenoids, including nine novel compounds for the Coniogramme genus, were identified through spectral data analysis.
- The identified compounds include (3S)-pteroside D, epi-pterosin L, pterosin D, onitin, pterosin Z, onitisin, onitisin-glucopyranoside, onitin-15-O-beta-D-glucopyranoside, (2S,3R)-pterosin-L-2'-O-beta-D-glucopyranoside, and (3R)-peterosin D-3-O-beta-D-glucopyranoside.
Impact:
- This research expands the known chemical diversity of sesquiterpenoids within the Coniogramme genus.
- The identification of novel compounds may lead to further investigation into their biological activities and potential applications.
- Provides a foundation for future studies on the chemotaxonomy and medicinal potential of Coniogramme maxima.
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