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[Triterpene compounds from Cirsium setosum].

Lingling Li¹, Zheng Sun, Xiaoya Shang

¹Beijing Key Laboratory of Bioactive Substances and Functional Foods, Beijing Union University, Beijing 100191, China.

Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica

|July 17, 2012

Summary

Researchers identified twelve chemical compounds from Cirsium setosum, including six novel compounds from this plant genus. These findings contribute to understanding the phytochemical profile of Cirsium species.

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Area of Science:

Phytochemistry
Natural Products Chemistry
Pharmacognosy

Background:

Cirsium setosum is a plant species with potential medicinal properties.
Previous research suggests cytotoxic activity in extracts of Cirsium species.
Understanding the chemical constituents is crucial for further investigation.

Purpose of the Study:

To isolate and identify chemical constituents from the cytotoxic petroleum ether extractive fractions of Cirsium setosum.
To characterize novel compounds within this plant genus.

Main Methods:

Extraction of Cirsium setosum using ethanol and petroleum ether.
Purification using silica gel, Sephadex LH-20, and preparative High-Performance Liquid Chromatography (HPLC).
Structure elucidation via 1D, 2D Nuclear Magnetic Resonance (NMR) and Mass Spectrometry (MS), supported by literature data.

Main Results:

Twelve compounds were isolated and identified: lupenyl acetate (1), lupeol (2), lupenone (3), beta-amyrin (4), psi-taraxasterol (5), psi-taraxasteryl acetate (6), taraxasteryl acetate (7), marsformoxide B (8), alpha-amyrenone (9), beta-amyrenone (10), taraxasterone (11), and psi-taraxasterone (12).
Compounds 3, 5, and 7-12 represent the first reported isolation from the Cirsium genus.
The study focused on triterpenoids.

Conclusions:

The petroleum ether fraction of Cirsium setosum ethanol extract contains a variety of triterpenoids.
Six of the identified compounds are reported for the first time in this genus, expanding the known phytochemical diversity of Cirsium.
Further research can explore the biological activities of these isolated compounds.