Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Sampling Methods: Overview

Sampling Methods: Overview

A sample refers to a smaller subset representative of a larger population. In analytical chemistry, studying or analyzing an entire population is often impractical or impossible. Therefore, samples are used to draw inferences and generalize the whole population. The sampling method selects individuals or items from a population to create a sample. Standard sampling methods include random, judgemental, systematic, stratified, and cluster sampling.
In analytical chemistry, the choice of sampling...

Sampling Methods: Sample Types

Sampling Methods: Sample Types

Sampling materials are classified into three main types: solid, liquid, and gas.
Solid samples include a variety of substances, such as sediments from water bodies, soil, metals, and biological tissues. Two standard methods for extracting sediments from water bodies are grab sampling and piston coring. Grab sampling involves using a device to collect a discrete sediment sample from the bottom of a water body with minimal disturbance. Grab samples do not always represent the entire area due to...

Convenience Sampling Method

Convenience Sampling Method

Sampling is a technique to select a portion (or subset) of the larger population and study that portion (the sample) to gain information about the population. Data are the result of sampling from a population. The sampling method ensures that samples are drawn without bias and accurately represent the population.
Convenience sampling is a non-random method of sample selection; this method selects individuals that are easily accessible and may result in biased data. For example, a marketing...

Sampling Plans

Sampling Plans

Sampling is a crucial step in analytical chemistry, allowing researchers to collect representative data from a large population. Common sampling methods include random, judgmental, systematic, stratified, and cluster sampling.
Random sampling is a method where each member of the population has an equal chance of being selected for the sample. It involves selecting individuals randomly, often using random number generators or lottery-type methods. For example, when analyzing the properties of a...

Downsampling

Downsampling

When considering a sampled sequence with zero values between sampling instants, one can replace it by taking every N-th value of the sequence. At these integer multiples of N, the original and sampled sequences coincide. This process, known as decimation, involves extracting every N-th sample from a sequence, thereby creating a more efficient sequence.
The Fourier transform of the decimated sequence reveals a combination of scaled and shifted versions of the original spectrum. This...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Bringing new technologies into regulatory space.

Bioanalysis·2012

Same author

2012 white paper on recent issues in bioanalysis and alignment of multiple guidelines.

Bioanalysis·2012

Same author

US FDA/EMA harmonization of their bioanalytical guidance/guideline and activities of the Global Bioanalytical Consortium.

Bioanalysis·2012

Same author

2011 White paper on recent issues in bioanalysis and regulatory findings from audits and inspections.

Bioanalysis·2011

Same author

Regulatory observations in bioanalytical determinations.

Bioanalysis·2010

Same author

Workshop report and follow-up--AAPS Workshop on current topics in GLP bioanalysis: Assay reproducibility for incurred samples--implications of Crystal City recommendations.

The AAPS journal·2009

Search research articles

Related Experiment Video

Updated: May 20, 2026

Microsampling in Targeted Mass Spectrometry-Based Protein Analysis of Low-Abundance Proteins

Microsampling in Targeted Mass Spectrometry-Based Protein Analysis of Low-Abundance Proteins

Published on: January 13, 2023

Perspectives on microsampling: DBS.

C T Viswanathan¹

¹CT Viswanathan & Associates Inc., Rockville, MD 20855, USA. vishct@gmail.com

|July 17, 2012

Summary

Dried blood spot microsampling offers advantages but lacks formal regulatory standards for pharmaceutical use. This article proposes a framework to establish standardized procedures for regulatory interactions, enhancing adoption.

Area of Science:

Pharmacokinetics and Drug Metabolism
Analytical Chemistry
Regulatory Science

Background:

Microsampling, specifically dried blood spot (DBS) methodology, is a recognized technique in scientific research.
Despite its recognition, a standardized approach for DBS implementation in pharmaceutical regulatory interactions is currently lacking.

Purpose of the Study:

To address the absence of formal standards for dried blood spot microsampling in the pharmaceutical industry.
To discuss the challenges and opportunities associated with the regulatory application of DBS technology.
To propose a framework for establishing standardized procedures for DBS in pharmaceutical regulatory contexts.

Main Methods:

Literature review of existing microsampling and DBS methodologies.

More Related Videos

Combined Invasive Subcortical and Non-invasive Surface Neurophysiological Recordings for the Assessment of Cognitive and Emotional Functions in Humans

Combined Invasive Subcortical and Non-invasive Surface Neurophysiological Recordings for the Assessment of Cognitive and Emotional Functions in Humans

Published on: May 19, 2016

Microdialysis of Excitatory Amino Acids During EEG Recordings in Freely Moving Rats

Microdialysis of Excitatory Amino Acids During EEG Recordings in Freely Moving Rats

Published on: November 8, 2018

Related Experiment Videos

Last Updated: May 20, 2026

Microsampling in Targeted Mass Spectrometry-Based Protein Analysis of Low-Abundance Proteins

Microsampling in Targeted Mass Spectrometry-Based Protein Analysis of Low-Abundance Proteins

Published on: January 13, 2023

Combined Invasive Subcortical and Non-invasive Surface Neurophysiological Recordings for the Assessment of Cognitive and Emotional Functions in Humans

Combined Invasive Subcortical and Non-invasive Surface Neurophysiological Recordings for the Assessment of Cognitive and Emotional Functions in Humans

Published on: May 19, 2016

Microdialysis of Excitatory Amino Acids During EEG Recordings in Freely Moving Rats

Microdialysis of Excitatory Amino Acids During EEG Recordings in Freely Moving Rats

Published on: November 8, 2018

Analysis of current regulatory landscapes and requirements.

Development of a conceptual framework for standardized DBS procedures.

Main Results:

Identification of key areas requiring standardization in DBS methodology for regulatory submissions.
Discussion of the benefits of standardized DBS approaches, including improved data quality and regulatory efficiency.
Presentation of a proposed framework outlining essential components for standardized DBS protocols.

Conclusions:

Standardized procedures for dried blood spot microsampling are crucial for its effective integration into pharmaceutical regulatory processes.
The proposed framework provides a foundation for developing consistent and reliable DBS methods, facilitating regulatory acceptance.
Adoption of standardized DBS protocols will enhance the utility of microsampling in drug development and regulatory decision-making.