Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Lineage Commitment

Lineage Commitment

Commitment is the process whereby stem cells:

Determination

Determination

During embryogenesis, cells become progressively committed to different fates through a two-step process: specification followed by determination. Specification is demonstrated by removing a segment of an early embryo, “neutrally” culturing the tissue in vitro—for example, in a petri dish with simple medium—and then observing the derivatives. If the cultured region gives rise to cell types that it would normally generate in the embryo, this means that it is specified. In contrast, determination...

Neural Circuits

Neural Circuits

Neural circuits and neuronal pools are two of the main structures found in the nervous system. Neural circuits are networks of neurons that work together to carry out a specific task or process. They consist of interconnected neurons and glial cells, which provide structural and metabolic support.
Neuronal pools are collections of nerve cells with similar functions and interact through chemical and electrical signals. These pools include both interneurons (the central neural circuit nodes that...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Millimeter-scale selective amplification in the developing visual cortex.

bioRxiv : the preprint server for biology·2026

Same author

Between the ambulance and academia: rethinking identity and competence in paramedics with reduced clinical exposure.

British paramedic journal·2026

Same author

Connectivity, Computation, and Plasticity of the Early Visual System.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2025

Same author

Development of coherent cortical responses reflects increased discriminability of feedforward inputs and their alignment with recurrent circuits.

Neuron·2025

Same author

Retinal waves reveal axial biases in modular patterns of cortical activity that predict future orientation preferences.

bioRxiv : the preprint server for biology·2025

Same author

Stereotyped Spatiotemporal Dynamics of Spontaneous Activity in Visual Cortex Prior to Eye Opening.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2025

Search research articles

Related Experiment Video

Updated: May 20, 2026

Lineage Tracing and Clonal Analysis in Developing Cerebral Cortex Using Mosaic Analysis with Double Markers (MADM)

Lineage Tracing and Clonal Analysis in Developing Cerebral Cortex Using Mosaic Analysis with Double Markers (MADM)

Published on: May 8, 2020

Specifying cortical circuits: a role for cell lineage.

Gordon B Smith¹, David Fitzpatrick

¹Max Planck Florida Institute, Jupiter, FL 33458, USA.

|July 17, 2012

Summary

This summary is machine-generated.

Neuronal lineage impacts cortical circuit development. Two studies reveal how cell origins influence neural connections and function, though differences prompt further research into cortical neuron development.

Area of Science:

Neuroscience
Developmental Neuroscience
Computational Neuroscience

Background:

Cortical circuit development is complex.
Neuronal connectivity and function are critical for brain activity.

More Related Videos

Live Imaging of Primary Cerebral Cortex Cells Using a 2D Culture System

Live Imaging of Primary Cerebral Cortex Cells Using a 2D Culture System

Published on: August 9, 2017

Differentiation of Mouse Embryonic Stem Cells into Cortical Interneuron Precursors

Differentiation of Mouse Embryonic Stem Cells into Cortical Interneuron Precursors

Published on: December 3, 2017

Related Experiment Videos

Last Updated: May 20, 2026

Lineage Tracing and Clonal Analysis in Developing Cerebral Cortex Using Mosaic Analysis with Double Markers (MADM)

Lineage Tracing and Clonal Analysis in Developing Cerebral Cortex Using Mosaic Analysis with Double Markers (MADM)

Published on: May 8, 2020

Live Imaging of Primary Cerebral Cortex Cells Using a 2D Culture System

Live Imaging of Primary Cerebral Cortex Cells Using a 2D Culture System

Published on: August 9, 2017

Differentiation of Mouse Embryonic Stem Cells into Cortical Interneuron Precursors

Differentiation of Mouse Embryonic Stem Cells into Cortical Interneuron Precursors

Published on: December 3, 2017

Understanding how neurons develop specific properties is an ongoing challenge.