Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin, heparin),...
Allergic Reactions02:06

Allergic Reactions

Overview
Hypersensitivity Reactions: Immune-Complex Reactions01:19

Hypersensitivity Reactions: Immune-Complex Reactions

Type III hypersensitivity reactions occur when antigen–antibody complexes form and activate the complement system. Normally, these complexes help the clearance of antigens by phagocytes and red blood cells. However, when large numbers of immune complexes are present, they can deposit in tissues—particularly in the walls of blood vessels—leading to inflammation and tissue injury. These deposits trigger complement activation and neutrophil recruitment, resulting in serum sickness, a systemic...
Hypersensitivities01:30

Hypersensitivities

Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial exposure to a...
Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Multicohort analysis unveils axon guidance pathways linking small for gestational age to spirometric restriction.

Nature communications·2026
Same author

Profiling Peripheral Blood with an Optimized, Multiplexed, Single-cell Multiome Approach Supports an Insulin-driven Asthma Subtype.

bioRxiv : the preprint server for biology·2026
Same author

PrecISE-a biomarker-stratified adaptive trial of 5 interventions in severe asthma: Final protocol and the baseline cohort.

The Journal of allergy and clinical immunology·2026
Same author

The Next Frontier Is Here: Targeted Systemic Therapies for Allergic and Immunologic Diseases.

The journal of allergy and clinical immunology. In practice·2026
Same author

The role of CC16 in the associations of preterm birth with lung function and asthma in adult life.

The Journal of allergy and clinical immunology·2025
Same author

Clinical predictors of breakthrough reactions during initial rapid drug desensitizations to platinum chemotherapeutics.

Allergy and asthma proceedings·2025

Related Experiment Video

Updated: May 20, 2026

Basophil Activation Test for Allergy Diagnosis
07:22

Basophil Activation Test for Allergy Diagnosis

Published on: May 31, 2021

Chapter 21: Urticaria and angioedema.

Tara F Carr, Carol A Saltoun

    Allergy and Asthma Proceedings
    |July 17, 2012
    PubMed
    Summary
    This summary is machine-generated.

    Urticaria, or hives, affects many people and involves mast cell activation. Chronic urticaria may be linked to autoimmune conditions like Hashimoto's disease.

    More Related Videos

    Measuring Local Anaphylaxis in Mice
    07:49

    Measuring Local Anaphylaxis in Mice

    Published on: October 14, 2014

    Related Experiment Videos

    Last Updated: May 20, 2026

    Basophil Activation Test for Allergy Diagnosis
    07:22

    Basophil Activation Test for Allergy Diagnosis

    Published on: May 31, 2021

    Measuring Local Anaphylaxis in Mice
    07:49

    Measuring Local Anaphylaxis in Mice

    Published on: October 14, 2014

    Area of Science:

    • Immunology
    • Dermatology

    Background:

    • Urticaria (hives) affects up to 20% of the population, characterized by itchy, raised lesions.
    • Its pathogenesis involves mast cell activation and histamine release, leading to edema and erythema.
    • Urticaria is often associated with angioedema, affecting different body parts.

    Purpose of the Study:

    • To review the characteristics, pathogenesis, and associations of urticaria.
    • To differentiate between acute and chronic urticaria.
    • To explore the autoimmune basis of chronic urticaria.

    Main Methods:

    • Literature review of urticaria pathogenesis and clinical presentation.
    • Classification of urticaria based on duration (acute vs. chronic).
    • Examination of associations with angioedema and autoimmune diseases.

    Main Results:

    • Acute urticaria (<6 weeks) often has identifiable triggers.
    • Chronic urticaria (>6 weeks) is frequently idiopathic or autoimmune-related.
    • A significant percentage of chronic urticaria patients have antibodies against IgE receptors or IgE, and an association with autoimmune hypothyroidism exists.

    Conclusions:

    • Urticaria pathogenesis involves mast cell mediators.
    • Chronic urticaria may have an autoimmune basis, including associations with Hashimoto's disease and specific autoantibodies.
    • Antihistamines are the primary treatment for urticaria.