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Related Concept Videos

Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin, heparin),...
Allergic Reactions02:06

Allergic Reactions

Overview
Taste Buds and Receptors01:20

Taste Buds and Receptors

Gustation, or the sense of taste, is intrinsically linked to the anatomical structures located on the tongue. This organ's surface, along with the entirety of the oral cavity, is adorned with stratified squamous epithelium. Evident on the tongue are elevated structures known as papillae (singular = papilla), which house the mechanisms for the transduction of gustatory stimuli. Four distinct types of papillae exist, each identified by their unique morphological attributes: the circumvallate,...
Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial exposure to a...
Allergic Drug Reactions01:27

Allergic Drug Reactions

Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing numerous...
Hypersensitivities01:30

Hypersensitivities

Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...

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Related Experiment Video

Updated: May 20, 2026

Mouse Body Temperature Measurement Using Infrared Thermometer During Passive Systemic Anaphylaxis and Food Allergy Evaluation
04:34

Mouse Body Temperature Measurement Using Infrared Thermometer During Passive Systemic Anaphylaxis and Food Allergy Evaluation

Published on: September 14, 2018

Chapter 23: Food allergy.

Rachel G Robison, Jacqueline A Pongracic

    Allergy and Asthma Proceedings
    |July 17, 2012
    PubMed
    Summary

    IgE-mediated food allergies typically develop rapidly after ingestion. While some childhood allergies like milk and eggs resolve, peanut, tree nut, and seafood allergies are often lifelong, emphasizing prompt epinephrine use.

    Area of Science:

    • Immunology
    • Allergology
    • Pediatrics

    Background:

    • IgE-mediated food allergy onset is rapid, occurring within 2 hours of ingestion.
    • Common allergens include milk, eggs, peanuts, soy, tree nuts, fish, shellfish, and wheat.
    • Asthma, delayed epinephrine use, and prior severe reactions are risk factors for fatal food-induced anaphylaxis.

    Purpose of the Study:

    • To summarize the key aspects of IgE-mediated food allergy, including onset, risk factors, common allergens, and immunological mechanisms.
    • To discuss the development of tolerance and the lifelong nature of certain food allergies.
    • To highlight the importance of epinephrine administration and current recommendations on allergen introduction for prevention.

    Main Methods:

    • Review of existing literature on IgE-mediated food allergy.

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    Last Updated: May 20, 2026

    Mouse Body Temperature Measurement Using Infrared Thermometer During Passive Systemic Anaphylaxis and Food Allergy Evaluation
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    Published on: September 14, 2018

    Antigenic Liposomes for Generation of Disease-specific Antibodies
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  • Analysis of risk factors for severe reactions and anaphylaxis.
  • Examination of immunological pathways, including T-helper type 2 cell responses.
  • Synthesis of data on tolerance development and allergen introduction guidelines.

    • Main Results:

    • Allergies to peanuts, tree nuts, and seafood are frequently lifelong, unlike milk and egg allergies which often resolve by age 16.
    • Food allergens are typically stable glycoproteins that elicit T-helper type 2 cell responses.
    • No evidence supports delaying solid food introduction beyond 4-6 months for atopic disease prevention.

    Conclusions:

    • Food allergy management requires education on prompt epinephrine autoinjector use.
    • Understanding the immunological basis and differing prognoses of food allergies is crucial.
    • Current evidence does not support delaying allergen introduction for primary prevention of atopic disease.