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Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase01:11

Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase

Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...
Therapeutic Drug Monitoring: Affecting Factors01:29

Therapeutic Drug Monitoring: Affecting Factors

Therapeutic Drug Monitoring (TDM) is the clinical practice of measuring specific drug levels in a patient's blood or body tissues to manage and optimize therapy. TDM is crucial for drugs with narrow therapeutic windows, like warfarin and phenytoin, where incorrect doses can lead to treatment failure or severe side effects. This monitoring ensures the dosage administered is within a safe and effective range. The factors affecting therapeutic drug monitoring include:Patient-Specific Factors:a.

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Stereotactic Radiosurgery for Gynecologic Cancer
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Stereotactic Radiosurgery for Gynecologic Cancer

Published on: April 17, 2012

Metronomic therapy for gynecologic cancers.

Wen-Hsiang Su1, Tien-Yu Ho, Yiu-Tai Li

  • 1Department of Obstetrics and Gynecology, Yee-Zen Hospital, Tao-Yuan, Taiwan.

Taiwanese Journal of Obstetrics & Gynecology
|July 17, 2012
PubMed
Summary

Metronomic chemotherapy, a lower-dose, continuous cytotoxic drug regimen, shows promise for managing advanced cancers by potentially inducing tumor dormancy. Further research is needed to optimize this approach for various tumor types.

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Area of Science:

  • Oncology
  • Cancer Therapeutics
  • Pharmacology

Background:

  • Systemic cytotoxic drugs are standard for advanced cancer, aiming to kill cancer cells but limited by host toxicity.
  • Traditional treatment focuses on maximum tolerated doses for tumor eradication.
  • Emerging concept views cancer as a chronic disease, exploring less toxic, continuous treatment strategies.

Purpose of the Study:

  • To review recent studies on metronomic chemotherapy mechanisms.
  • To explore its application in managing various tumors, particularly gynecologic cancers.

Main Methods:

  • Review of recent scientific literature on metronomic chemotherapy.
  • Analysis of studies investigating mechanisms and applications in cancer management.

Main Results:

  • Metronomic chemotherapy involves continuous, lower-dose cytotoxic drugs, often combined with targeted therapies.
  • This approach aims to achieve tumor dormancy rather than eradication.
  • Growing interest in optimizing drug selection, dosage, schedule, and tumor-specific applications.

Conclusions:

  • Metronomic chemotherapy represents a shift towards chronic disease management for cancer.
  • Further research is essential to refine drug choices, dosing, and scheduling for optimal efficacy and safety.
  • This strategy holds potential for improved patient care, especially in gynecologic oncology.