Mitral annular plane systolic excursion as a surrogate for left ventricular ejection fraction

Area of Science:

• Cardiology
• Medical Imaging
• Echocardiography

Background:

• Left ventricular function assessment is crucial in echocardiography but often subjective.
• Mitral annular plane systolic excursion (MAPSE) is a potential surrogate for left ventricular function.
• Reader variability can impact the accuracy of left ventricular function assessment.

Purpose of the Study:

• To evaluate the accuracy of MAPSE in predicting left ventricular ejection fraction (EF).
• To establish MAPSE as a reliable, objective measure for cardiac function assessment.
• To reduce subjectivity in echocardiographic estimations of left ventricular function.

Main Methods:

• Retrospective analysis of 600 echocardiographic studies.
• MAPSE measured by an untrained observer, compared to expert-determined EF.
• Development of a predictive algorithm using a calibration cohort (300 studies).
• Validation of the algorithm in a separate cohort (300 studies).

Main Results:

• An algorithm was developed to predict EF from MAPSE measurements.
• Gender-specific regression equations were used for intermediate MAPSE values.
• The algorithm demonstrated high accuracy (82%-86%) in predicting EF.
• MAPSE showed high sensitivity (73%-92%) and specificity (81%-100%) for EF prediction.

Conclusions:

• MAPSE measurement by an untrained observer is a highly accurate predictor of EF.
• MAPSE provides a reliable and objective alternative for assessing left ventricular function.
• This method can potentially reduce reader discordance in echocardiography.