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Influence of flavonoids and lanthanides on kappa-carrageenin rat tail thrombosis
H Bekemeier1, M Gabor, R Hirschelmann
1Department of Pharmacology, Martin Luther University, Halle-Wittenberg, FRG.
Experimental Pathology
|January 1, 1990
Abstract:
Rat tail thrombosis (RTT) induced by i.v. injection of kappa-carrageenin was not inhibited by p.o. or i.p. administration of the aglucon of rutin, quercetin, but it was slightly inhibited by rutoside-containing Venoruton. The RTT was significantly inhibited by didymlaevulinate, Helodym 88, whereas samarium-containing Phlogosol gave inconsistent results because of the solvent propylene glycol. The RTT model is suitable to detect substances of the flavonoid and lanthanide types with weak antithrombotic activity.