Nano-sized clusters of a teicoplanin ψ-aglycon-fullerene conjugate. Synthesis, antibacterial activity and aggregation
Szilvia Tollas1, Ilona Bereczki, Attila Sipos
1Department of Pharmaceutical Chemistry, University of Debrecen, Medical and Health Science Center, Egyetem tér 1, H-4032 Debrecen, Hungary.
European Journal of Medicinal Chemistry
|July 17, 2012
Abstract:
Glycopeptide antibiotic derivative teicoplanin ψ-aglycone has been bound covalently to a fullerenopyrrolidine derivative using azide-alkyne 1,3-dipolar cycloaddition reaction. The aggregation of the antibiotic-fullerene conjugate in aqueous solution has been studied. The conjugate exhibited antibacterial activity against enterococci resistant to teicoplanin.
