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Simultaneous PET/MRI Imaging During Mouse Cerebral Hypoxia-ischemia

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Simultaneous PET-MRI in oncology: a solution looking for a problem?

Thomas E Yankeelov¹, Todd E Peterson, Richard G Abramson

¹Institute of Imaging Science, Vanderbilt University, Nashville, TN 37232, USA. thomas.yankeelov@vanderbilt.edu

Magnetic Resonance Imaging

|July 17, 2012

Summary

Integrated positron emission tomography-magnetic resonance imaging (PET-MRI) offers new cancer imaging possibilities. Simultaneous PET-MRI data may improve tumor assessment and therapy response evaluation, balancing benefits against costs.

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Area of Science:

Medical Imaging
Oncology
Radiochemistry

Background:

Integrated positron emission tomography-magnetic resonance imaging (PET-MRI) scanners enable simultaneous data acquisition.
The clinical utility of simultaneous PET-MRI requires balancing its advantages against significant costs and resource demands.

Purpose of the Study:

To review key areas where simultaneous PET-MRI measurements are expected to impact clinical and research studies in oncology.
To evaluate the potential value of PET-MRI in cancer management by considering its advantages and disadvantages.

Main Methods:

Review of current literature and evidence regarding integrated PET-MRI applications in cancer.
Analysis of specific applications including MR-based motion correction, improved PET data reconstruction, arterial input function characterization, and dual-modality contrast agents.

Main Results:

Simultaneous PET-MRI facilitates MR-based motion corrections for enhanced PET data reconstruction.
Improved arterial input function characterization for PET kinetic modeling is achievable.
Potential for dual-modality contrast agents and enhanced patient comfort.

Conclusions:

Widespread PET-MRI adoption hinges on demonstrating significant improvements in assessing tumor status and therapy response.
Quantitative MRI combined with PET biomarkers shows promise for personalized cancer management.
Further evidence is needed to solidify the value of PET-MRI in routine cancer care.