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Canonical Wnt Signaling Pathway

Canonical Wnt Signaling Pathway

The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which results in tumor...

Canonical Wnt Signaling Pathway

Canonical Wnt Signaling Pathway

The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which results in tumor...

Non-Canonical Wnt Signaling Pathways

Non-Canonical Wnt Signaling Pathways

Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...

Non-Canonical Wnt Signaling Pathways

Non-Canonical Wnt Signaling Pathways

Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...

Notch Signaling Pathway

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...

Notch Signaling Pathway

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...

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Related Experiment Video

Updated: May 20, 2026

Modeling Paracrine Noncanonical Wnt Signaling In Vitro

Modeling Paracrine Noncanonical Wnt Signaling In Vitro

Published on: December 10, 2021

WNT secretion and signalling in human disease.

Patrick Herr¹, George Hausmann, Konrad Basler

¹Institute of Molecular Life Sciences, University of Zürich, Winterthurerstrasse 190, CH-8057 Zürich, Switzerland.

Trends in Molecular Medicine

|July 17, 2012

Summary

Wnt signalling is crucial for development and disease, especially cancer. New research highlights the importance of Wnt ligand secretion, opening doors for targeted cancer therapies.

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Last Updated: May 20, 2026

Modeling Paracrine Noncanonical Wnt Signaling In Vitro

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Published on: December 10, 2021

The Soft Agar Colony Formation Assay

The Soft Agar Colony Formation Assay

Published on: October 27, 2014

Area of Science:

Molecular biology
Developmental biology
Cancer research

Background:

Wnt signalling is vital in embryonic development and implicated in human diseases like cancer.
Historically, research emphasized signal transduction, neglecting Wnt ligand secretion.
Aberrant Wnt levels are increasingly linked to various diseases, prompting interest in secretion mechanisms.

Purpose of the Study:

To review proteins involved in Wnt ligand secretion and plasma membrane signalling.
To discuss therapeutic strategies targeting aberrant Wnt signalling pathways.
To highlight the significance of studying Wnt biogenesis for disease treatment.

Main Methods:

Literature review of Wnt secretion and signalling proteins.
Analysis of Wnt pathway components at the plasma membrane.
Discussion of therapeutic approaches for Wnt-induced diseases.

Main Results:

Identified key proteins essential for Wnt ligand secretion.
Detailed the role of these proteins in Wnt signalling at the plasma membrane.
Outlined potential therapeutic avenues based on Wnt secretion and signalling.

Conclusions:

Understanding Wnt ligand biogenesis is critical for developing targeted therapies.
Focusing on Wnt secretion offers new strategies to combat Wnt-driven diseases.
Further research into Wnt secretion pathways can lead to novel treatments for cancer and other diseases.