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Preclinical testing of Peruvian anti-bothropic anti-venom against Bothrops andianus snake venom

Francisco S Schneider1, Maria C Starling, Clara G Duarte

  • 1Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Av. Antonio Carlos 6627, CP: 486, CEP: 31270-901, Belo Horizonte, Minas Gerais, Brazil.

Toxicon : Official Journal of the International Society on Toxinology
|July 17, 2012
PubMed

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Preclinical development consists of a series of tests that ensure the safety and efficacy of a new therapeutic compound before it is tested in humans. There are four main phases to this process. First, safety pharmacology tests are conducted to ensure the drug does not produce any acutely harmful effects. These tests examine parameters such as bronchoconstriction, cardiac dysrhythmias, blood pressure changes, and ataxia. Next, preliminary toxicological testing is performed to determine the...