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Related Concept Videos

Schizophrenia01:17

Schizophrenia

Schizophrenia, a term introduced by Swiss psychiatrist Eugen Bleuler in 1911, describes a severe psychological disorder marked by profound disruptions in attention, thought processes, language, emotion, and interpersonal relationships. The core feature of schizophrenia is psychosis — a state characterized by a fundamental detachment from reality. This disconnection manifests through distorted logic, impaired perception, and atypical behavior, severely affecting the lives of those diagnosed.
Psychological and Sociocultural Causes of Schizophrenia01:29

Psychological and Sociocultural Causes of Schizophrenia

Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
Biological Causes of Schizophrenia01:29

Biological Causes of Schizophrenia

Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin studies.
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders01:27

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within the...
Psychosis: Goals of Pharmacotherapy01:26

Psychosis: Goals of Pharmacotherapy

Antipsychotic drugs are a crucial treatment method for acute and chronic psychoses, bipolar illness, and behavioral disorders. The selection of these drugs depends on several factors, including the state of the disease, clinical judgment, possible drug interactions, and the patient's sensitivity to adverse effects. In immediate scenarios, such as delirium and dementia, short-term treatment with low doses of high-potency typical or atypical agents can effectively manage symptom exacerbation. For...
Psychosis and Antipsychotic Drugs: Overview01:28

Psychosis and Antipsychotic Drugs: Overview

The term "psychosis" refers to a spectrum of mental disorders characterized by abnormal thoughts, perceptions, and behaviors. It can manifest as mood disorders, dementia, delirium with psychotic features, substance-induced psychosis with psychotic features, brief psychotic disorder, delusional disorder, schizoaffective disorder, and schizophrenia. Among all these disorders, schizophrenia is the most common psychotic disorder, affecting 1% of the worldwide population. Psychotic symptoms in all...

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Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis
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Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis

Published on: November 21, 2013

Early-onset schizophrenia.

Helmut Remschmidt1, Frank Theisen

  • 1Department of Child and Adolescent Psychiatry, Philipps University, Marburg, Germany. remschm@med.uni-marburg.de

Neuropsychobiology
|July 17, 2012
PubMed
Summary
This summary is machine-generated.

Childhood-onset schizophrenia has a poor prognosis, often progressing into adulthood. Early diagnosis and treatment are crucial for managing this severe mental health condition.

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Area of Science:

  • Child and Adolescent Psychiatry
  • Neuroscience
  • Psychology

Background:

  • Schizophrenia beginning in childhood or adolescence presents unique challenges.
  • Understanding the course and outcome is critical for effective intervention.

Purpose of the Study:

  • To summarize existing findings on the prognosis of early-onset schizophrenia.
  • To identify factors influencing the course and outcome of childhood and adolescent schizophrenia.

Main Methods:

  • Review and synthesis of available study findings on schizophrenia with onset before adulthood.
  • Analysis of prognostic indicators including age of onset, symptom presentation, premorbid personality, and family history.

Main Results:

  • Schizophrenia starting before age 13 has a very poor prognosis, often progressing throughout life.
  • Acute onset with positive symptoms indicates a better prognosis than insidious onset with negative symptoms.
  • Favorable premorbid personality, no family history, good family cooperation, and rapid treatment response correlate with better outcomes.
  • Childhood-onset schizophrenia generally has a worse course and outcome than adult-onset schizophrenia, with a higher suicide rate.

Conclusions:

  • Early-onset schizophrenia carries a significantly worse prognosis compared to adult-onset cases.
  • Prognosis is influenced by a complex interplay of clinical, personality, and familial factors.
  • Further longitudinal research is needed to confirm findings, particularly regarding suicide rates.