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Modeling and Evaluation of Murine Diabetic Cardiomyopathy Model

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Exercise-induced cardiac performance in autoimmune (type 1) diabetes is associated with a decrease in myocardial

Rajprasad Loganathan¹, Lesya Novikova, Igor G Boulatnikov

¹Department of Physical Therapy and Rehabilitation Science, University of Kansas Medical Center, Kansas City, Kansas 66160-7601, USA.

Journal of Applied Physiology (Bethesda, Md. : 1985)

|July 17, 2012

Summary

This summary is machine-generated.

Exercise training improves cardiac function in diabetic rats by reducing elevated diacylglycerol (DAG) levels, a key factor in diabetic cardiovascular complications. This suggests DAG modulation is crucial for exercise benefits in diabetes.

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Accelerated Type 1 Diabetes Induction in Mice by Adoptive Transfer of Diabetogenic CD4+ T Cells

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Published on: May 6, 2013

Area of Science:

Biochemistry
Cardiovascular Physiology
Diabetology

Background:

Diabetic cardiovascular complications are linked to elevated diacylglycerol (DAG) and protein kinase C (PKC) signaling.
Exercise training is known to improve cardiac performance in Type 1 diabetes, but its underlying mechanisms involving PKC signaling remain unclear.

Purpose of the Study:

To investigate if exercise training modulates PKC-βII signaling to alleviate cardiac abnormalities in a Type 1 diabetes model.
To determine the role of diacylglycerol (DAG) levels in exercise-induced improvements in diabetic heart function.

Main Methods:

Utilized bio-breeding diabetic resistant rats, a model for Type 1 diabetes.
Assigned rats to exercised and non-exercised groups, both diabetic and non-diabetic.
Conducted treadmill training, followed by left ventricular (LV) hemodynamic assessment, myocardial histology, and electron microscopy after 8 weeks.

Main Results:

Diabetic rats exhibited compromised LV function, increased collagen deposition, and reduced viable mitochondria compared to non-diabetic rats.
Myocardial DAG levels were elevated in diabetic hearts, while PKC-βII levels and activity remained unchanged.
Exercise training attenuated the structural and functional cardiac deterioration in diabetic rats, correlating with decreased myocardial DAG levels.

Conclusions:

Exercise training effectively mitigates cardiac dysfunction in a Type 1 diabetes model.
The beneficial effects of exercise on diabetic cardiac performance may be mediated by the prevention of increased myocardial DAG levels.