Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pulmonary Function Tests01:25

Pulmonary Function Tests

Pulmonary Function Tests (PFTs)
Pulmonary Function Tests are crucial diagnostic tools for assessing respiratory function, particularly in patients with chronic respiratory disorders. They comprehensively evaluate lung volumes, ventilatory function, breathing mechanics, diffusion, and gas exchange. These tests help diagnose pulmonary diseases and play a significant role in monitoring disease progression, evaluating disability, and assessing response to therapy.
PFTs involve using a spirometer, a...
Respiratory Volumes and Capacities I01:26

Respiratory Volumes and Capacities I

Assessing the respiratory rate and rhythm for a complete minute is crucial for evaluating the breathing pattern. Even a minor increase in the patient's average respiratory rate, by as little as three to five breaths per minute, is an early and vital indicator of respiratory distress. Patients with a respiratory rate exceeding twenty-four breaths per minute require close monitoring to determine the physiological alterations. This careful observation is essential for prompt recognition and...
Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies01:27

Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies

Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History
Lung Capacity01:47

Lung Capacity

The air in the lungs is measured in volumes and capacities. Lung volume measures reflect the amount of air taken in, released, or left over after a lung function, like a single inhalation. Lung capacity measures are sums of two or more lung volume measures.
Respiratory Volumes and Capacities01:22

Respiratory Volumes and Capacities

The respiratory system is responsible for the intake of oxygen and the expulsion of carbon dioxide from the body. Respiratory volumes describe the volume of air in the lungs at different phases of the respiratory cycle. Tidal volume is the air breathed in and out during normal, quiet breathing. Inspiratory reserve volume is the air that can be forcefully inspired beyond the tidal volume. In contrast, expiratory reserve volume refers to the air that can be expelled from the lungs after a normal...
Respiratory Capacities01:24

Respiratory Capacities

Respiratory capacities are crucial indicators of lung function, representing the maximum amount of air an individual's respiratory system can handle during various breathing phases.
One key metric is the Inspiratory Capacity (IC), which represents the maximum amount of air that can be inhaled with full effort. IC is calculated by summing the tidal volume and inspiratory reserve volume, typically ranging from 2.4 to 3.6 liters.
The Functional Residual Capacity (FRC) represents the air in the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Erratum: Large meta-analysis of genome-wide association studies identifies five loci for lean body mass.

Nature communications·2017
Same author

Exome-wide association study of plasma lipids in >300,000 individuals.

Nature genetics·2017
Same author

Genetically defined elevated homocysteine levels do not result in widespread changes of DNA methylation in leukocytes.

PloS one·2017
Same author

IgG glycosylation and DNA methylation are interconnected with smoking.

Biochimica et biophysica acta. General subjects·2017
Same author

The dynamics of smoking-related disturbed methylation: a two time-point study of methylation change in smokers, non-smokers and former smokers.

BMC genomics·2017
Same author

Identification of novel risk loci for restless legs syndrome in genome-wide association studies in individuals of European ancestry: a meta-analysis.

The Lancet. Neurology·2017

Related Experiment Video

Updated: May 20, 2026

Employing the Forced Oscillation Technique for the Assessment of Respiratory Mechanics in Adults
06:11

Employing the Forced Oscillation Technique for the Assessment of Respiratory Mechanics in Adults

Published on: February 9, 2022

Spirometric reference values for advanced age from a South german population.

Stefan Karrasch1, Claudia Flexeder, Jürgen Behr

  • 1Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, Ludwig-Maximilians-University, Munich, Germany. stefan.karrasch @ med.uni-muenchen.de

Respiration; International Review of Thoracic Diseases
|July 17, 2012
PubMed
Summary
This summary is machine-generated.

New spirometry reference values for advanced age were established, showing slight differences from previous equations but good agreement for small airway disease indicators. This aids accurate lung function diagnosis in older adults.

More Related Videos

Home-Based Prescribed Pulmonary Exercise in Patients with Stable Chronic Obstructive Pulmonary Disease
07:10

Home-Based Prescribed Pulmonary Exercise in Patients with Stable Chronic Obstructive Pulmonary Disease

Published on: August 24, 2019

Dual Test Gas Pulmonary Diffusing Capacity Measurement During Exercise in Humans Using the Single-Breath Method
08:44

Dual Test Gas Pulmonary Diffusing Capacity Measurement During Exercise in Humans Using the Single-Breath Method

Published on: February 2, 2024

Related Experiment Videos

Last Updated: May 20, 2026

Employing the Forced Oscillation Technique for the Assessment of Respiratory Mechanics in Adults
06:11

Employing the Forced Oscillation Technique for the Assessment of Respiratory Mechanics in Adults

Published on: February 9, 2022

Home-Based Prescribed Pulmonary Exercise in Patients with Stable Chronic Obstructive Pulmonary Disease
07:10

Home-Based Prescribed Pulmonary Exercise in Patients with Stable Chronic Obstructive Pulmonary Disease

Published on: August 24, 2019

Dual Test Gas Pulmonary Diffusing Capacity Measurement During Exercise in Humans Using the Single-Breath Method
08:44

Dual Test Gas Pulmonary Diffusing Capacity Measurement During Exercise in Humans Using the Single-Breath Method

Published on: February 2, 2024

Area of Science:

  • Pulmonary Medicine
  • Respiratory Physiology
  • Biostatistics

Background:

  • Accurate spirometry reference equations are crucial for diagnosing lung function disorders.
  • Existing spirometric prediction values often underrepresent older adult populations.
  • Establishing age-specific reference values is essential for valid diagnostic interpretation.

Purpose of the Study:

  • To derive new spirometric reference values for middle-aged and older adults.
  • To compare these new values with existing prediction equations.
  • To improve the accuracy of lung function diagnostics in aging populations.

Main Methods:

  • Spirometry was conducted on 592 non-smoking individuals aged 42-89 in the KORA-F4 and KORA-Age cohorts.
  • Quantile regression analysis was used to establish median and lower limit of normal equations.
  • Key spirometry indices analyzed included FEV1, FVC, FEV1/FVC, PEF, FEF25, FEF50, and FEF75.

Main Results:

  • New reference equations for spirometry indices in middle and advanced age were generated.
  • Forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC) were slightly higher than in previous equations.
  • Forced expiratory flow rates, particularly at lower lung volumes, showed good agreement with recent data, especially in older individuals.

Conclusions:

  • The study provides updated spirometric reference equations for a South German population, covering middle and advanced age.
  • Minor deviations from existing equations suggest potential regional variations in lung function among older Caucasians.
  • These findings contribute to more accurate lung function assessment in aging individuals.