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Updated: May 20, 2026

Spot Variation Fluorescence Correlation Spectroscopy for Analysis of Molecular Diffusion at the Plasma Membrane of Living Cells
Published on: November 12, 2020
Eisosomes and plasma membrane organization
Agustina Olivera-Couto1, Pablo S Aguilar
1Institut Pasteur de Montevideo, 11400 Montevideo, Uruguay.
Abstract:
Membrane compartmentalization allows the spatial segregation of different functions, such as signal transduction and protein trafficking, and ensures their fidelity and efficiency. Eisosomes constitute nanoscale furrow-like invaginations of the plasma membrane where proteins and lipids segregate. The intense interest elicited by eisosomes over the last few years has led to the identification and molecular characterization of their key constituents. This review addresses eisosome structure, functions and its implications for the mechanistic understanding of curvature-induced membrane nanodomains formation and signaling compartmentalization in living cells.
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