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POEMS syndrome - a unique presentation of a rare paraneoplastic syndrome
J Livingston1, C Cobiella, M A Hall-Craggs
1Accident and Emergency Department, Basildon and Thurrock University Hospital, Nethermayne, Essex, UK. judithlivingston@hotmail.co.uk
Abstract:
POEMS (peripheral neuropathy, organomegaly, endocrinopathy, M protein, skin changes) syndrome is a rare multisystem paraneoplastic disorder. A 40-year-old male with a history of peripheral neuropathy and erectile dysfunction presented with a pathological fracture of the neck of the femur, found to be a solitary plasmacytoma. Additional unusual features included splenomegaly, hyperprolactinaemia and skin changes. The patient had a total hip replacement at a specialist orthopaedic hospital and is due to undergo radiotherapy to the femoral lesion and autologous stem cell transplantation.
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