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Atrophic gastritis is associated with coronary artery disease

Takafumi Senmaru1, Michiaki Fukui, Muhei Tanaka

  • 1Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, 465 Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto 602-8566, Japan.

Journal of Clinical Biochemistry and Nutrition
|July 17, 2012
PubMed

Insights

Atrophic gastritis, a chronic stomach inflammation, is linked to a higher prevalence of coronary artery disease. This finding suggests a potential independent risk factor for heart disease in the general population.

Area of Science:

  • Gastroenterology
  • Cardiology
  • Epidemiology

Background:

  • Atrophic gastritis involves chronic gastric mucosa inflammation, often due to Helicobacter pylori.
  • Helicobacter pylori infection is a known risk factor for coronary artery disease.
  • The direct relationship between atrophic gastritis and coronary artery disease remains under-investigated.

Purpose of the Study:

  • To investigate the association between atrophic gastritis and the prevalence of coronary artery disease.
  • To determine if atrophic gastritis is an independent risk factor for coronary artery disease in a Japanese population.

Main Methods:

  • Serum pepsinogen levels were used to diagnose atrophic gastritis (PG I ≤ 70 ng/mL, PG I/II ratio ≤ 3.0).
  • A cohort of 2,633 Japanese subjects was analyzed.
  • Logistic regression analysis adjusted for cardiovascular risk factors was performed.

Main Results:

  • Atrophic gastritis was diagnosed in 20.2% of subjects (531/2,633).
  • The prevalence of coronary artery disease was significantly higher in the atrophic gastritis-positive group (5.8%) compared to the negative group (2.8%, p=0.0005).
  • Atrophic gastritis was independently associated with coronary artery disease (OR, 1.67; 95% CI, 1.03-2.72) after adjustments.

Conclusions:

  • Atrophic gastritis is an independent risk factor for coronary artery disease.
  • Chronic gastric inflammation may play a role in the development of coronary artery disease.
  • These findings highlight a potential link between gastrointestinal health and cardiovascular risk.

Keywords:
atrophic gastritischronic inflammationcoronary artery diseasepepsinogen

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