Related Experiment Video

Updated: May 20, 2026

Cercosporin-Photocatalyzed [4+1]- and [4+2]-Annulations of Azoalkenes Under Mild Conditions
07:12

Cercosporin-Photocatalyzed [4+1]- and [4+2]-Annulations of Azoalkenes Under Mild Conditions

Published on: July 17, 2020

2-[4-(Chloro-meth-yl)phen-oxy]-4,6-dimeth-oxy-pyrimidine

Shi-Hong Shen, Kui Hu, Li Sun

    Acta Crystallographica. Section E, Structure Reports Online
    |July 17, 2012
    PubMed

    Abstract:

    The title compound, C(13)H(13)ClN(2)O(3), was synthesized in the course of the search for novel bioactive pyrimidine derivatives. The C-O-C angle at the phen-oxy O atom is widened to 119.87 (18)°. The dihedral angle between the pyrimidine and benzene rings is 64.2 (3)°.

    More Related Videos

    Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs
    10:44

    Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs

    Published on: May 15, 2019

    Synthesis of Antiviral Tetrahydrocarbazole Derivatives by Photochemical and Acid-catalyzed C-H Functionalization via Intermediate Peroxides (CHIPS)
    06:34

    Synthesis of Antiviral Tetrahydrocarbazole Derivatives by Photochemical and Acid-catalyzed C-H Functionalization via Intermediate Peroxides (CHIPS)

    Published on: June 20, 2014

    Related Experiment Videos

    Last Updated: May 20, 2026

    Cercosporin-Photocatalyzed [4+1]- and [4+2]-Annulations of Azoalkenes Under Mild Conditions
    07:12

    Cercosporin-Photocatalyzed [4+1]- and [4+2]-Annulations of Azoalkenes Under Mild Conditions

    Published on: July 17, 2020

    Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs
    10:44

    Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs

    Published on: May 15, 2019

    Synthesis of Antiviral Tetrahydrocarbazole Derivatives by Photochemical and Acid-catalyzed C-H Functionalization via Intermediate Peroxides (CHIPS)
    06:34

    Synthesis of Antiviral Tetrahydrocarbazole Derivatives by Photochemical and Acid-catalyzed C-H Functionalization via Intermediate Peroxides (CHIPS)

    Published on: June 20, 2014

    Related Concept Videos

    Phase II Reactions: Methylation Reactions01:17

    Phase II Reactions: Methylation Reactions

    Methylation is a phase II biotransformation process involving the attachment of a methyl group to a substrate. Enzymes known as methyltransferases orchestrate this reaction.
    The mechanism of methylation unfolds in two stages. The first stage sees a methyltransferase enzyme facilitating the transfer of a methyl group from S-adenosylmethionine (SAM) to the substrate, forming S-adenosylhomocysteine (SAH). The second stage involves further metabolism of SAH into homocysteine, which can be recycled...
    Structure and Nomenclature of Epoxides02:38

    Structure and Nomenclature of Epoxides

    Cyclic ethers are heterocyclic compounds with an oxygen atom in the ring along with carbon atoms. They are named depending on the number of carbon atoms present in their ring system. Cyclic ethers with a three-membered ring system are called “oxirane”, four-membered ring systems as “oxetane”, five-membered ring systems as “oxolane”, and six-membered ring systems as “oxane”. The cyclic structure of these rings imposes angle strain, and this strain is more in the ring having a smaller number of...
    Experimental Determination of Chemical Formula02:37

    Experimental Determination of Chemical Formula

    The elemental makeup of a compound defines its chemical identity, and chemical formulas are the most concise way of representing this elemental makeup. When a compound’s formula is unknown, measuring the mass of its constituent elements is often the first step in determining the formula experimentally.

    Articles linked to this work by shared authors, journal, and citation graph.

    Agonist Binding Reshapes the Kinetic Landscape and Allosteric Communication of APLNR Toward Activation-Competent States.

    International journal of molecular sciences·2026

    Integration of Multiresonance Heterocyclic Aromatic Hydrocarbons for Fully Resonant B/N-Doped Hetero[8]helicenes with Long-Wavelength Ultra-Narrow-Band Emission.

    Organic letters·2026

    SSGJ-601 versus Ranibizumab for Macular Edema Secondary to Branch Retinal Vein Occlusion: 52-Week Results from a Phase 3 Study.

    Ophthalmology. Retina·2026

    Electrochromic gated photoacoustic-electrochemiluminescent bimodal biosensing via domino cascade amplification for exosomes.

    Biosensors & bioelectronics·2026

    Interpretable dynamic quantitative vascular morphometry features using SHAP for anti-angiogenic therapy response prediction.

    Science advances·2026

    Review on isotachophoresis in trace biochemical sample analysis: state of art and future prospects.

    Journal of chromatography. A·2026

    Crystal structure of 1-(piperidin-1-yl)butane-1,3-dione.

    Acta crystallographica. Section E, Structure reports online·2015

    Crystal structure of methyl 1-methyl-3,5-diphenyl-7-tosyl-3,6,7,11b-tetra-hydro-pyrazolo-[4',3':5,6]pyrano[3,4-c]quinoline-5a(5H)-carboxyl-ate.

    Acta crystallographica. Section E, Structure reports online·2015

    Crystal structure of 4-amino-1-(4-methyl-benz-yl)pyridinium bromide.

    Acta crystallographica. Section E, Structure reports online·2015

    Crystal structure of (Z)-3-benz-yloxy-6-[(2-hy-droxy-anilino)methyl-idene]cyclo-hexa-2,4-dien-1-one.

    Acta crystallographica. Section E, Structure reports online·2015

    Crystal structure of bis-(1-benzyl-1H-1,2,4-triazole) perchloric acid monosolvate.

    Acta crystallographica. Section E, Structure reports online·2015

    Crystal structure of 2-(di-phenyl-phos-phanyl)phenyl 4-(hy-droxy-meth-yl)benzoate.

    Acta crystallographica. Section E, Structure reports online·2015

    Structure-activity profiling of indazole-based derivatives as spinster homolog 2 (Spns2)-dependent S1P release inhibitors.

    Bioorganic & medicinal chemistry letters·2026

    Triterpenoids and lignans from the stems of Tripterygium wilfordii and their hepatoprotective activities.

    Fitoterapia·2026

    An integrated in vitro and in silico approach to evaluate the safety and wound healing potential of Dracocephalum moldavica L. seed oil.

    Toxicology in vitro : an international journal published in association with BIBRA·2026

    Unraveling the allosteric inhibition mechanism of TLR2 by CU-CPT22: A combined DFT and enhanced sampling MD study.

    Journal of molecular graphics & modelling·2026

    Discovery of pyrimidine-based dual CDK2/TrkA inhibitors: Synthesis, antiproliferative activity, and mechanistic insights.

    Bioorganic chemistry·2026

    Oleanolic acid-selenocyanate hybrids trigger replication-associated DNA damage responses and suppress tumour growth in vitro and in vivo.

    Bioorganic chemistry·2026
    See all related articles
    JoVE
    x logofacebook logolinkedin logoyoutube logo
    ABOUT JoVE
    OverviewLeadershipBlogJoVE Help Center
    AUTHORS
    Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
    LIBRARIANS
    TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
    RESEARCH
    JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
    EDUCATION
    JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
    Terms & Conditions of Use
    Privacy Policy
    Policies
    Jove
    Visualize
    Contact Us