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Updated: May 20, 2026

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
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Published on: January 19, 2016

(E)-4-Methyl-N-[(5-nitro-thio-phen-2-yl)methyl-idene]aniline

Umit Ceylan, Sümeyye Gümüş, Erbil Ağar

    Acta Crystallographica. Section E, Structure Reports Online
    |July 17, 2012
    PubMed
    Summary

    The crystal structure of C(12)H(10)N(2)O(2)S reveals specific molecular geometry. The benzene and nitro-thiophene rings exhibit a slight dihedral angle, indicating near-planar arrangement.

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    Direct alkylation is not a suitable method for synthesizing amines because it produces polyalkylated products. Gabriel synthesis is the most preferred method to exclusively make primary amines. The method uses phthalimide, which contains a protected form of nitrogen that participates in alkylation only once to predominantly give primary amines.
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