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Updated: May 20, 2026

Preparation of Stable Bicyclic Aziridinium Ions and Their Ring-Opening for the Synthesis of Azaheterocycles
Published on: August 22, 2018
2-[4-(Azido-meth-yl)phen-yl]benzonitrile.
1Department of Applied Chemistry, Nanjing College of Chemical Technology, Nanjing 210048, People's Republic of China.
Researchers synthesized a novel compound, C(14)H(10)N(4), using specific chemical reactions. Crystal analysis revealed a notable dihedral angle and weak intermolecular interactions.
Area of Science:
- Organic Chemistry
- Crystallography
Background:
- Biphenyl derivatives are important scaffolds in medicinal chemistry and materials science.
- Understanding the structural properties of novel organic compounds is crucial for their potential applications.
Purpose of the Study:
- To synthesize and characterize a new biphenyl-based compound.
- To investigate the crystal structure and intermolecular interactions of the synthesized compound.
Main Methods:
- Synthesis of the title compound (C(14)H(10)N(4)) via reaction of 4'-(bromo-meth-yl)biphenyl-2-carbonitrile with sodium azide.
- Single-crystal X-ray diffraction analysis to determine the molecular structure and crystal packing.
Main Results:
- The synthesized compound has the molecular formula C(14)H(10)N(4).
- The crystal structure exhibits a dihedral angle of 46.41(7)° between the biphenyl rings.
- Weak intermolecular C-H⋯π interactions were identified in the crystal lattice.
Conclusions:
- A novel biphenyl derivative was successfully synthesized and characterized.
- The observed dihedral angle and intermolecular interactions provide insights into the solid-state behavior of this compound.
- Further studies could explore the potential applications of this compound based on its structural features.
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