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Published on: April 6, 2019
Isolation of antitrypanosomal compounds from Vitis repens, a medicinal plant of Myanmar
Khine Swe Nyunt1, Ahmed Elkhateeb, Yusuke Tosa
1Laboratory of Bioorganic Chemistry, Division of Applied Bioscience, Research Faculty of Agriculture, Hokkaido University, Sapporo 060-8589, Japan.
Abstract:
Bioactivity-guided fractionation of an ethanolic extract of Vitis repens led to the isolation of resveratrol (1), 11-O-acetyl bergenin (2), and stigmast-4-en-3-one (3). The compounds were examined for their in vitro antitrypanosomal activities against trypomastigotes of Trypanosoma evansi. Resveratrol showed antitrypanosomal activity with an IC50 value of 0.13 microM, whereas 11-O-acetyl bergenin and stigmast-4-en-3-one exhibited IC50 values of 0.17 and 0.15 microM, respectively.