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The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
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Updated: May 20, 2026

Multidisciplinary Approach to Obesity Management: A Case Report
05:10

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Published on: May 30, 2025

Pharmacotherapy for weight management.

Princy Louis Palatty1, Elroy Saldanha

  • 1Department of Pharmacology, FMMC, Mangalore.

The Journal of the Association of Physicians of India
|July 18, 2012
PubMed
Summary

Effective weight management involves lifestyle changes, therapy, and medications. Newer hormonal and receptor-based approaches aim to reduce side effects associated with current drugs like orlistat and sibutramine.

Area of Science:

  • Obesity research
  • Pharmacology
  • Immunotherapy

Background:

  • Weight management encompasses lifestyle modification, behavioral therapy, pharmacotherapy, and surgery.
  • Current popular drugs like orlistat and sibutramine have significant side effects and contraindications.
  • Antidepressants, such as fluoxetine, can serve as an adjunct therapy for obesity.

Purpose of the Study:

  • To review current and emerging strategies in weight management.
  • To highlight the limitations of existing pharmacotherapies.
  • To introduce novel, targeted approaches with potentially fewer adverse effects.

Main Methods:

  • Review of existing literature on weight management strategies.
  • Analysis of pharmacotherapy options, including orlistat, sibutramine, and fluoxetine.

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  • Exploration of emerging hormonal, receptor-based, and immunotherapeutic concepts.

    • Main Results:

    • Pharmacotherapy for weight management is limited by side effects and contraindications.
    • Novel hormonal and receptor-based therapies show promise in reducing adverse effects.
    • Immunotherapy, specifically anti-obesity vaccines, represents a future direction.

    Conclusions:

    • Emerging weight management strategies focus on targeted mechanisms to minimize side effects.
    • Hormonal and receptor-based therapies offer a promising alternative to traditional drugs.
    • Anti-obesity vaccines are an innovative immunotherapy approach for future consideration.