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Association between moderate renal insufficiency and cardiovascular events in a general population: Tehran lipid and

Farhad Hosseinpanah1, Maryam Barzin, Hosein Aghayan Golkashani

  • 1Obesity Research Center, Research Institute for Endocrine Science, Shahid Beheshti University of Medical Sciences, Tehran, Iran. fhospanah@endocrine.ac.ir

BMC Nephrology
|July 18, 2012
PubMed

Insights

Chronic kidney disease (CKD) was not an independent risk factor for cardiovascular disease (CVD) in this Tehranian population study. The association between CKD and CVD may be explained by other co-occurring traditional risk factors.

Area of Science:

  • Nephrology
  • Cardiology
  • Epidemiology

Background:

  • Chronic kidney disease (CKD) is a potential risk factor for cardiovascular disease (CVD), but evidence from community-based studies is conflicting.
  • The interaction between CKD and body mass index (BMI) in relation to CVD risk requires further investigation.

Purpose of the Study:

  • To evaluate the association between CKD and CVD events in a Tehranian population.
  • To assess potential interactions between CKD and BMI on CVD risk.

Main Methods:

  • A cohort of 6,209 participants from the Tehran Lipid and Glucose Study, free of prior CVD, were followed for 9.1 years.
  • Glomerular filtration rate (GFR) was estimated using the MDRD formula to define CKD (eGFR <60 ml/min per 1.73 m²).
  • Statistical analyses adjusted for age, sex, and other traditional CVD risk factors, and examined interactions with BMI categories.

Main Results:

  • 22.2% of participants had CKD, predominantly stage 3a.
  • Moderate CKD was not an independent predictor of CVD events after full adjustment (HR: 1.14, 95% CI 0.91-1.42).
  • No significant interaction was found between CKD status and BMI categories concerning CVD risk (P = 0.2).

Conclusions:

  • CKD is not an independent risk factor for CVD events in this community-based Tehranian cohort.
  • The observed higher CVD prevalence in individuals with mild to moderate CKD may be attributed to the co-occurrence of traditional CVD risk factors.
Abstract

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