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Updated: May 20, 2026
06:15
Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia
Published on: August 9, 2024
Dysplastic nevi
Michele J Farber1, Edward R Heilman, Robert J Friedman
1Jefferson Medical College, Thomas Jefferson University, 1020 Walnut Street, Philadelphia, PA 19107, USA.
Dermatologic Clinics
|July 18, 2012
Summary
Dysplastic nevi increase melanoma risk and share genetic mutations with melanoma, despite diagnostic challenges. Understanding these atypical moles is crucial for patient management and early detection.
Area of Science:
- Dermatology
- Oncology
- Pathology
Background:
- Dysplastic nevi (DN) have been recognized since 1978.
- Their biological potential and clinical significance remain subjects of ongoing research and debate.
- Growing evidence links DN to an increased risk of melanoma development.
Purpose of the Study:
- To provide a comprehensive review of dysplastic nevi.
- To consolidate information on their history, epidemiology, biology, genetics, clinical presentation, histopathology, and management.
- To clarify the role of DN in melanoma risk stratification.
Main Methods:
- Literature review and synthesis of existing research.
- Analysis of historical data, epidemiological studies, and genetic investigations.
- Compilation of clinical and histopathologic diagnostic criteria.
- Review of current management guidelines.
Main Results:
- Dysplastic nevi are associated with a substantial increase in melanoma risk.
- Genetic mutations found in DN suggest a transitional state between benign nevi and melanoma.
- DN can mimic melanoma clinically, posing diagnostic challenges for clinicians.
Conclusions:
- Dysplastic nevi represent a significant risk factor for melanoma.
- Understanding the biology and genetics of DN is key to their management.
- Effective diagnostic and management strategies are essential for patients with dysplastic nevi.
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