Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chronic Inflammation: Introduction01:12

Chronic Inflammation: Introduction

Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Selective grazing in the heterotrophic dinoflagellate Oxyrrhis marina: Effects of prey type, size, temperature, and nutrient limitation.

Journal of phycology·2026
Same author

Retraction Note: Time-of-day immunochemotherapy in non-small cell lung cancer: a randomized phase 3 trial.

Nature medicine·2026
Same author

Treatment for intermediate and advanced-stage hepatocellular carcinoma: does systemic therapy synergize the therapeutic efficacy of TACE?

Frontiers in immunology·2026
Same author

Microbial community and functional characteristics across the water-sediment continuum in typical rivers of the Yellow River Delta.

Environmental research·2026
Same author

<i>FATP4</i> Switches Cellular Lipid Utilization via the PI3K-AKT Pathway in Goat Preadipocytes.

Animals : an open access journal from MDPI·2026
Same author

Discovery of an orally bioavailable selenium-containing Polθ inhibitor with a dual mechanism of DNA damage and immune activation for HR-deficient cancers.

European journal of medicinal chemistry·2026
Same journal

[Clinical significance and molecular mechanisms of m<sup>6</sup>A modification in oral squamous cell carcinoma].

Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology·2026
Same journal

[Oral-gut axis: the microbial and immune bridge linking periodontitis to inflammatory bowel disease].

Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology·2026
Same journal

[Progress in basic research on hydrogel-based drug delivery systems for the treatment of peri-implantitis].

Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology·2026
Same journal

[Application of splint to relieve muscle symptom caused by clenching in a mandible osteomyelitis patient: a case report].

Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology·2026
Same journal

[Digital technology assisted rehabilitation with an adhesive retained auricular prosthesis: a case report].

Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology·2026
Same journal

[Exploring innovative approaches by Zhu Xitao to promote the modernization and internationalization of Chinese stomatology].

Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology·2026
See all related articles

Related Experiment Video

Updated: May 20, 2026

Ultrasonographic Evaluation of Salivary Glands for Sjogren's Syndrome: Diagnostic and Monitoring Insights
07:25

Ultrasonographic Evaluation of Salivary Glands for Sjogren's Syndrome: Diagnostic and Monitoring Insights

Published on: October 13, 2023

[IgG4 expression in chronic sclerosing submaxillaritis].

Ke Sun1, Li-jun Wang, Hong-tian Yao

  • 1Department of Pathology, The First Affiliated Hospital, College of Medicine, Zhejiang Univerisity, Hangzhou 310003, China.

Zhonghua Kou Qiang Yi Xue Za Zhi = Zhonghua Kouqiang Yixue Zazhi = Chinese Journal of Stomatology
|July 18, 2012
PubMed
Summary
This summary is machine-generated.

Chronic sclerosing submaxillaritis (CSS) is linked to IgG4-related diseases. Recognizing this connection is crucial for effective treatment and managing potential systemic involvement.

More Related Videos

Surgical Technique for Superior Cervical Ganglionectomy in a Murine Model
07:30

Surgical Technique for Superior Cervical Ganglionectomy in a Murine Model

Published on: December 2, 2022

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

Related Experiment Videos

Last Updated: May 20, 2026

Ultrasonographic Evaluation of Salivary Glands for Sjogren's Syndrome: Diagnostic and Monitoring Insights
07:25

Ultrasonographic Evaluation of Salivary Glands for Sjogren's Syndrome: Diagnostic and Monitoring Insights

Published on: October 13, 2023

Surgical Technique for Superior Cervical Ganglionectomy in a Murine Model
07:30

Surgical Technique for Superior Cervical Ganglionectomy in a Murine Model

Published on: December 2, 2022

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

Area of Science:

  • Pathology
  • Immunology
  • Sialadenitis

Context:

  • Chronic sclerosing submaxillaritis (CSS) is a rare condition affecting the submandibular gland.
  • Understanding its clinicopathologic features is essential for accurate diagnosis and management.

Purpose:

  • To analyze the clinicopathologic features of 9 cases of chronic sclerosing submaxillaritis (CSS).
  • To investigate the potential association of CSS with IgG4-related sclerosing diseases.

Summary:

  • Analysis of 9 CSS cases revealed painless, firm submandibular masses with characteristic histological findings including lymphocyte and plasma cell infiltration.
  • Immunohistochemistry showed elevated IgG4-positive plasma cells (mean 186/HPF) and a high IgG4:IgG ratio (0.71).
  • Three cases presented with IgG4-associated systemic disease, supporting CSS as part of the IgG4-related disease spectrum.

Impact:

  • This study highlights the importance of recognizing CSS as a manifestation of IgG4-related sclerosing diseases.
  • Accurate diagnosis and determining systemic involvement are critical for appropriate treatment strategies, including steroid therapy.
  • Establishing follow-up protocols is necessary for patients diagnosed with CSS.