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Cognitive enhancers, also known as "smart drugs," are substances used to enhance memory, mental alertness, and concentration. These can be natural or synthetic and improve cognition in conditions like Alzheimer's disease (AD) and other neurodegenerative diseases. Some common examples include caffeine, amphetamines, methylphenidate, modafinil, arecoline, donepezil, vortioxetine, and piracetam. These enhancers work on the principle of synaptic plasticity and altered circuit function. They...
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Updated: May 20, 2026

Lipid Supplementation for Longevity and Gene Transcriptional Analysis in Caenorhabditis elegans
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Polyunsaturated fatty acids as putative cognitive enhancers.

S Yehuda1

  • 1Department of Psychology, Bar Ilan University, Ramat Gan, Israel. syehuda31@gmail.com

Medical Hypotheses
|July 18, 2012
PubMed
Summary

Polyunsaturated essential fatty acids (PUFAs) are vital for brain health, impacting cognitive functions. Supplementing PUFAs can improve cognitive deficits related to aging and stress.

Area of Science:

  • Neuroscience
  • Biochemistry
  • Cognitive Science

Background:

  • Polyunsaturated essential fatty acids (PUFAs) are crucial for cognitive, learning, and memory functions.
  • PUFAs directly influence neuronal membrane structure and stability.
  • Brain PUFA levels impact central nervous system physiology, biochemistry, and disorders.

Purpose of the Study:

  • To investigate the role of PUFAs in neuronal membranes.
  • To elucidate the effects of PUFAs on brain function and cognitive health.
  • To explore the link between PUFA deficiency/supplementation and cognitive deficits.

Main Methods:

  • The study summarizes existing research on PUFA's effects on the brain.
  • It reviews the impact of PUFA levels on neuronal membranes.

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  • It analyzes cognitive outcomes associated with PUFA deficiency and supplementation.

    • Main Results:

    • Deficiency in brain PUFAs leads to cognitive deficits.
    • PUFA supplementation can rehabilitate cognitive deficits.
    • These effects are observed in conditions like ADHD, stress, and aging.

    Conclusions:

    • PUFAs are essential for maintaining cognitive function.
    • Neuronal membrane integrity is key to PUFA's cognitive benefits.
    • PUFA supplementation holds therapeutic potential for cognitive disorders.