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Related Concept Videos

Dementia01:30

Dementia

Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual.
Dementia l: Introduction01:22

Dementia l: Introduction

Dementia is an acquired, progressive syndrome characterized by a decline in multiple cognitive domains severe enough to impair daily functioning and reduce independence. Although memory loss is a central feature, the diagnosis requires additional deficits involving language, executive function, visuospatial skills, judgment, calculation, or abstract reasoning. These cognitive impairments reflect underlying neurodegenerative or vascular processes that gradually disrupt neuronal networks...
Alzheimer Disease l: Introduction01:29

Alzheimer Disease l: Introduction

Alzheimer disease is a chronic, progressive, and irreversible neurodegenerative disorder and the most common cause of dementia in older adults. It leads to gradual neuronal loss, causing cognitive decline, behavioral changes, and loss of functional independence.Risk Factors and EtiologyThe disease is multifactorial. Age is the strongest risk factor, with prevalence doubling every 5 years after age 65. Genetic factors include mutations in genes such as APP, PSEN1, and PSEN2, which are associated...
Psychoneuroimmunology: Diabetes and Cancer01:19

Psychoneuroimmunology: Diabetes and Cancer

Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
Depression: Overview01:18

Depression: Overview

Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
Depressive Disorders: Etiology01:27

Depressive Disorders: Etiology

Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...

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Related Experiment Video

Updated: May 20, 2026

Using Retinal Imaging to Study Dementia
09:17

Using Retinal Imaging to Study Dementia

Published on: November 6, 2017

Depression and the risk for dementia.

Lars Vedel Kessing1

  • 1Psychiatric Center Copenhagen, Rigshospitalet, University Hospital of Copenhagen, Denmark. lars.vedel.kessing@regionh.dk

Current Opinion in Psychiatry
|July 18, 2012
PubMed
Summary

Depression can be a long-term dementia risk factor or an early sign. Antidepressant treatment may influence dementia risk, highlighting the need to consider depression and dementia types.

Area of Science:

  • Neurology
  • Psychiatry
  • Gerontology

Background:

  • Depression is linked to a higher risk of developing dementia.
  • The precise relationship between depression and dementia remains unclear.

Purpose of the Study:

  • To review recent studies on whether depression is a dementia prodrome or independent risk factor.
  • To examine how depression type, dementia type, and antidepressant treatment affect this association.

Main Methods:

  • Literature review of recent studies.
  • Analysis of findings concerning depression subtypes and dementia development.
  • Evaluation of antidepressant treatment's role.

Main Results:

  • Early-onset or recurrent depression may be long-term dementia risk factors.

Related Experiment Videos

Last Updated: May 20, 2026

Using Retinal Imaging to Study Dementia
09:17

Using Retinal Imaging to Study Dementia

Published on: November 6, 2017

  • Recent depressive symptoms might indicate a prodromal dementia phase.
  • Long-term antidepressant use may reduce dementia risk, varying by depression type.

    • Conclusions:

    • Understanding the depression-dementia link requires considering specific depression and dementia types.
    • The impact of drug treatment on dementia risk in depressed individuals needs further investigation.