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Related Experiment Video

Updated: May 20, 2026

Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification
10:37

Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification

Published on: November 15, 2017

Imaging beyond the proteome.

Pamela V Chang1, Carolyn R Bertozzi

  • 1Department of Chemistry, University of California, Berkeley, 94720, USA.

Chemical Communications (Cambridge, England)
|July 18, 2012
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

Proteomics01:33

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term proteomics...

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Molecular imaging advances enable visualization of non-protein molecules within cells. New technologies expand cellular and molecular imaging beyond proteins to lipids, metabolites, and modifications.

Area of Science:

  • Biomedical imaging
  • Cellular biology
  • Molecular biology

Background:

  • Early 20th-century imaging relied on macroscopic and morphological differences.
  • A shift towards cellular and molecular imaging aims to visualize biological processes.
  • Molecular imaging has rapidly advanced, particularly for protein visualization.

Purpose of the Study:

  • To highlight recent technologies for imaging non-proteinaceous molecules.
  • To expand the scope of molecular imaging beyond the proteome.
  • To enable visualization of diverse cellular components.

Main Methods:

  • Review of recently developed molecular imaging technologies.
  • Focus on methodologies for non-protein molecule detection.
  • Application to lipids, glycans, nucleic acids, metabolites, and post-translational modifications.

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Imaging Protein-protein Interactions in vivo
11:15

Imaging Protein-protein Interactions in vivo

Published on: October 10, 2010

Related Experiment Videos

Last Updated: May 20, 2026

Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification
10:37

Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification

Published on: November 15, 2017

Imaging Protein-protein Interactions in vivo
11:15

Imaging Protein-protein Interactions in vivo

Published on: October 10, 2010

Main Results:

  • Emergence of novel imaging techniques for diverse molecular targets.
  • Demonstration of capabilities beyond protein imaging.
  • Successful visualization of lipids, ions, glycans, nucleic acids, metabolites, and protein modifications.

Conclusions:

  • Recent technological advancements significantly broaden the scope of molecular imaging.
  • These new methods allow for the visualization of a wider range of cellular molecules.
  • This expansion is crucial for a comprehensive understanding of cellular processes.