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Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting
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Increasing lymphatic microvessel density in primary pterygia.

Shiqi Ling1, Lingyi Liang, Haotian Lin

  • 1Department of Ophthalmology, Third Affiliated Hospital, Guangzhou, China. lingshiqi123@163.com

Archives of Ophthalmology (Chicago, Ill. : 1960)
|July 18, 2012
PubMed
Summary

Lymphatic microvessel density (LMVD) significantly increases in advanced pterygia (grades 2 and 3). VEGF-C may drive this lymphangiogenesis, impacting pterygium growth.

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Area of Science:

  • Ophthalmology
  • Vascular Biology
  • Pathology

Background:

  • Pterygia are fibrovascular growths on the conjunctiva.
  • The role of lymphatic vessels in pterygium development is not fully understood.

Purpose of the Study:

  • To investigate lymphatic microvessel density (LMVD) in primary pterygia.
  • To correlate LMVD with pterygium grade, size, and growth factor expression.

Main Methods:

  • Immunohistochemistry using CD31 and LYVE-1 antibodies on 88 pterygia and 7 control conjunctivae.
  • Real-time PCR to measure VEGF-A and VEGF-C mRNA expression.
  • Analysis of LMVD, blood microvessel density, and pterygium dimensions.

Main Results:

  • Normal conjunctiva showed minimal lymphatic vessels.
  • LMVD was significantly elevated in grade 2 and 3 pterygia compared to grade 1.
  • LMVD correlated with pterygium size and blood microvessel density.
  • VEGF-C mRNA expression strongly correlated with LMVD in all grades; VEGF-A correlated only in grade 1.

Conclusions:

  • Lymphatic microvessel proliferation is a key feature of advanced pterygia.
  • VEGF-C upregulation is implicated in pterygium lymphangiogenesis.